| Salvage of circulating hypoxanthine by tissues of the mouse. | |
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MedLine Citation:
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PMID: 6667423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoxanthine is an inefficient precursor of purine nucleotides in mouse tissues. In vitro, mouse erythrocytes salvage less than 10% of hypoxanthine (10 microM) added to whole blood in 30 min of incubation at 37 degrees C. In vivo, circulating hypoxanthine is rapidly degraded (greater than 90% in 10 min) to allantoin and uric acid. All tissues examined (other than erythrocytes) converted small amounts of hypoxanthine to nucleotides, with kidney and lung being the most active tissues examined. It is estimated that less than 2% of circulating hypoxanthine is salvaged in the mouse; the remainder is catabolized. |
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Authors:
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J D Moyer; J F Henderson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire Volume: 61 ISSN: 0714-7511 ISO Abbreviation: Can. J. Biochem. Cell Biol. Publication Date: 1983 Nov |
Date Detail:
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Created Date: 1984-03-27 Completed Date: 1984-03-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302763 Medline TA: Can J Biochem Cell Biol Country: CANADA |
Other Details:
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Languages: eng Pagination: 1153-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine Nucleotides
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biosynthesis Allantoin / biosynthesis Animals Erythrocytes / metabolism Guanine Nucleotides / biosynthesis Hypoxanthine Hypoxanthines / metabolism* Mice / metabolism* Tissue Distribution Uric Acid / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Adenine Nucleotides; 0/Guanine Nucleotides; 0/Hypoxanthines; 68-94-0/Hypoxanthine; 69-93-2/Uric Acid; 97-59-6/Allantoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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