| Salvage chemotherapy with amrubicin and platinum for relapsed thymic carcinoma: experience in six cases. | |
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MedLine Citation:
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PMID: 19415537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been reported that cisplatin-based chemotherapy shows beneficial effects in certain patients with advanced thymic carcinoma. However, the usefulness of salvage therapy has not been reported. We focused on a new anthracycline agent, amrubicin, combined with platinum compounds as salvage chemotherapy in patients with thymic carcinoma. Six cases of unresectable and locally advanced thymic carcinoma relapsed from prior cisplatin-containing chemotherapy were treated with amrubicin (30-40 mg/m(2) day 1-3) plus platinum compounds (cisplatin 60 mg/m(2) day 1 or nedaplatin 70 mg/m(2) day 1) chemotherapy as salvage chemotherapy. Two patients showed a partial response. However, Grade 3/4 neutropenia and thrombocytopenia occurred in all and two of the patients, respectively. We conclude that thymic carcinoma is sensitive to platinum-based chemotherapy and that amrubicin appears to have significant activity against thymic carcinoma. The major toxicity is hematological toxicities. |
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Authors:
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Tomonobu Koizumi; Toshihiko Agatsuma; Takashi Ichiyama; Toshiki Yokoyama; Atsuhito Ushiki; Yoshimichi Komatsu; Tsuyoshi Tanabe; Takashi Kobayashi; Sumiko Yoshikawa; Masanori Yasuo; Hiroshi Yamamoto; Keishi Kubo; Tsutomu Hachiya |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article Date: 2009-05-05 |
Journal Detail:
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Title: Medical oncology (Northwood, London, England) Volume: 27 ISSN: 1559-131X ISO Abbreviation: Med. Oncol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-30 Completed Date: 2011-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9435512 Medline TA: Med Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 392-6 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Shinshu University School of Internal Medicine, 3-1-1 Asahi Matsumoto, 390-8621 Matsumoto, Japan. tomonobu@shinshu-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anthracyclines / administration & dosage Antibiotics, Antineoplastic / administration & dosage Antineoplastic Combined Chemotherapy Protocols / administration & dosage* Female Humans Male Middle Aged Neoplasm Recurrence, Local / drug therapy*, pathology Platinum Compounds / administration & dosage Recurrence / prevention & control Salvage Therapy* / methods Thymoma / drug therapy*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Anthracyclines; 0/Antibiotics, Antineoplastic; 0/Platinum Compounds; 0/amrubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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