Document Detail


Salvage chemotherapy with amrubicin and platinum for relapsed thymic carcinoma: experience in six cases.
MedLine Citation:
PMID:  19415537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been reported that cisplatin-based chemotherapy shows beneficial effects in certain patients with advanced thymic carcinoma. However, the usefulness of salvage therapy has not been reported. We focused on a new anthracycline agent, amrubicin, combined with platinum compounds as salvage chemotherapy in patients with thymic carcinoma. Six cases of unresectable and locally advanced thymic carcinoma relapsed from prior cisplatin-containing chemotherapy were treated with amrubicin (30-40 mg/m(2) day 1-3) plus platinum compounds (cisplatin 60 mg/m(2) day 1 or nedaplatin 70 mg/m(2) day 1) chemotherapy as salvage chemotherapy. Two patients showed a partial response. However, Grade 3/4 neutropenia and thrombocytopenia occurred in all and two of the patients, respectively. We conclude that thymic carcinoma is sensitive to platinum-based chemotherapy and that amrubicin appears to have significant activity against thymic carcinoma. The major toxicity is hematological toxicities.
Authors:
Tomonobu Koizumi; Toshihiko Agatsuma; Takashi Ichiyama; Toshiki Yokoyama; Atsuhito Ushiki; Yoshimichi Komatsu; Tsuyoshi Tanabe; Takashi Kobayashi; Sumiko Yoshikawa; Masanori Yasuo; Hiroshi Yamamoto; Keishi Kubo; Tsutomu Hachiya
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article     Date:  2009-05-05
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  27     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-30     Completed Date:  2011-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  392-6     Citation Subset:  IM    
Affiliation:
First Department of Internal Medicine, Shinshu University School of Internal Medicine, 3-1-1 Asahi Matsumoto, 390-8621 Matsumoto, Japan. tomonobu@shinshu-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anthracyclines / administration & dosage
Antibiotics, Antineoplastic / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local / drug therapy*,  pathology
Platinum Compounds / administration & dosage
Recurrence / prevention & control
Salvage Therapy* / methods
Thymoma / drug therapy*,  pathology
Chemical
Reg. No./Substance:
0/Anthracyclines; 0/Antibiotics, Antineoplastic; 0/Platinum Compounds; 0/amrubicin

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