| Salt substitution: a low-cost strategy for blood pressure control among rural Chinese. A randomized, controlled trial. | |
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MedLine Citation:
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PMID: 17885542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Dietary sodium and potassium consumption is associated with blood pressure levels. The objective of this study was to define a practical and low-cost method for the control of blood pressure by modification of these dietary cations in rural Chinese. METHODS: This study was a double-blind, randomized, controlled trial designed to establish the long-term effects of a reduced-sodium, high-potassium salt substitute (65% sodium chloride, 25% potassium chloride, 10% magnesium sulphate) compared to normal salt (100% sodium chloride) on blood pressure among high-risk individuals. Following a 4-week run-in period on salt substitute, participants were randomly assigned to replace their household salt with either the study salt substitute or normal salt for a 12-month period. RESULTS: The mean age of the 608 randomized participants was 60 years and 56% of them were female. Sixty-four percent had a history of vascular disease and 61% were taking one or more blood pressure-lowering drugs at entry. Mean baseline blood pressure was 159/93 mmHg (SD 26/14). The mean overall difference in systolic blood pressure between randomized groups was 3.7 mmHg (95% confidence interval 1.6-5.9, P < 0.001). There was strong evidence that the magnitude of this reduction increased over time (P = 0.001) with the maximum net reduction of 5.4 mmHg (2.3-8.5) achieved at 12 months. There were no detectable effects on diastolic blood pressure. CONCLUSION: Salt substitution produced a substantial and sustained systolic blood pressure reduction in this population, and should be actively promoted as a low-cost alternate or adjunct to drug therapy for people consuming significant quantities of salt. |
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Authors:
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 25 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-21 Completed Date: 2008-01-02 Revised Date: 2009-01-07 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 2011-8 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure / drug effects China Double-Blind Method Female Humans Hypertension / diet therapy*, physiopathology, prevention & control Magnesium Sulfate / administration & dosage, adverse effects Male Middle Aged Potassium Chloride / administration & dosage, adverse effects Risk Factors Rural Population Sodium Chloride, Dietary / administration & dosage*, adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Sodium Chloride, Dietary; 7447-40-7/Potassium Chloride; 7487-88-9/Magnesium Sulfate |
| Comments/Corrections | |
Comment In:
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Nat Clin Pract Cardiovasc Med. 2008 Apr;5(4):186-7
[PMID:
18227813
]
Curr Hypertens Rep. 2008 Jun;10(3):173-4 [PMID: 18765085 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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