Document Detail


Salt stress induces programmed cell death in Thellungiella halophila suspension-cultured cells.
MedLine Citation:
PMID:  20417988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thellungiella halophila (T. halophila) suspension-cultured cells were used to gain knowledge of the pathway of programmed cell death (PCD) in halophytes under salt stress. Several apoptotic-like features occurred in T. halophila cells after exposure to 300 mM NaCl, including the retraction of the plasma membrane from the cell wall, nuclear condensation, DNA laddering and the release of cytochrome c accompanying the increase of caspase 3-like protease activity. This process resulted in ultrastructural changes of mitochondria and Golgi bodies, and autophagy was also induced by high salinity stress. DNA laddering and caspase 3-like activity were inhibited prior to the inhibition of cell death by a specific caspase 3 inhibitor, Ac-DEVD-CHO. The results indicate that 300 mM NaCl stress-induced PCD in T. halophila is similar to animal apoptosis, and this process occurs partly through a caspase 3-like dependent pathway.
Authors:
Jin Wang; Xinrong Li; Yubing Liu; Xin Zhao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-24
Journal Detail:
Title:  Journal of plant physiology     Volume:  167     ISSN:  1618-1328     ISO Abbreviation:  J. Plant Physiol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882059     Medline TA:  J Plant Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1145-51     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier GmbH. All rights reserved.
Affiliation:
Extreme Stress Resistance and Biotechnology Laboratory, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou, China. wangjinlzb@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Brassicaceae / cytology*,  drug effects*,  metabolism,  ultrastructure
Cell Survival / drug effects
Cysteine Proteinase Inhibitors / pharmacology
In Situ Nick-End Labeling
Microscopy, Electron, Transmission
Oligopeptides / pharmacology
Signal Transduction / drug effects
Sodium Chloride / pharmacology
Chemical
Reg. No./Substance:
0/Cysteine Proteinase Inhibitors; 0/Oligopeptides; 0/acetyl-aspartyl-glutamyl-valyl-aspartal; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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