Document Detail


Salt sensitivity and insulin resistance in normotensives.
MedLine Citation:
PMID:  9288538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Among hypertensive patients salt sensitivity and insulin resistance are commonly observed together. We investigated if a causal relationship already exists in young normotensive adults. With a standardized dietary regimen we determined salt sensitivity in 35 male volunteers by measuring diastolic blood pressure (24-hours-RR-recording). Insulin resistance was tested using hyperinsulinaemic-euglycaemic-clamp-technique by de Fronzo after a freely chosen diet, after 7 days of salt loading (260 mmol/d) and after 7 days of salt restriction (60 mmol/d). Data from euglycaemic-clamp technique were available from 27 subjects. 18 of them (67%) could be characterized as salt resistant; 9 persons (33%) were salt sensitive. Glucose infusion rate, mean glucose and insulin concentrations were measured in plasma, metabolic clearance rate (MCR) and indices of insulin sensitivity (ISI) were calculated. The results of MCR and ISI show large interindividual variances. There were no differences between the salt sensitive and salt resistant group regarding the mean insulin concentrations and also the mean glucose uptake in the steady state clamp period and also the calculated MCR and ISI. Comparing the periods of different salt intake, there were no differences between salt loading and salt restriction. Whereas salt sensitivity can already be shown in the normotensive state, with this experimental design a changed insulin sensitivity is not detectable. This supports the idea, that insulin resistance is not causally linked with salt sensitivity. It may be a secondary phenomenon of salt induced hypertension.
Authors:
S Gruska; E Wolf; I Jendral; B Wedler; G Kraatz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association     Volume:  105 Suppl 2     ISSN:  0947-7349     ISO Abbreviation:  Exp. Clin. Endocrinol. Diabetes     Publication Date:  1997  
Date Detail:
Created Date:  1997-10-16     Completed Date:  1997-10-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9505926     Medline TA:  Exp Clin Endocrinol Diabetes     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  22-6     Citation Subset:  IM    
Affiliation:
Department for Internal Medicine, Ernst-Moritz-Arndt University Greifswald, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism*
Blood Pressure* / drug effects
Body Height
Body Mass Index
Body Weight
Cross-Over Studies
Double-Blind Method
Electrolytes / urine
Energy Intake
Glucose / metabolism
Humans
Insulin / blood
Insulin Resistance*
Male
Random Allocation
Reference Values
Regression Analysis
Sodium, Dietary* / pharmacology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Electrolytes; 0/Sodium, Dietary; 11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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