| Salt sensitivity in essential hypertension as determined by the cosinor method. | |
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MedLine Citation:
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PMID: 4077226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A method of data reduction for the statistical examination of mean arterial pressure in essential hypertensive subjects to determine salt sensitivity was examined. A computerized method was used to estimate the best-fitting cosine curve for data collected every 30 minutes for 24 hours. The effect of sodium loading on the cosinor parameters (mesor, amplitude, and acrophase) in 45 subjects with essential hypertension and five normotensive control subjects was assessed. Twenty-five percent of the essential hypertensive subjects in the study were found to be salt-sensitive with a statistically significant increase in their mesors with sodium loading (p less than 0.05). The non-salt-sensitive group was found to contain a subpopulation with a statistically significant decrease in their mesor with sodium loading (p less than 0.05). Sodium loading appears to affect the lability of mean arterial pressure independently of mesor changes. |
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Authors:
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C C Bittle; D J Molina; F C Bartter |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hypertension Volume: 7 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1985 Nov-Dec |
Date Detail:
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Created Date: 1986-01-29 Completed Date: 1986-01-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 989-94 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure / drug effects* Circadian Rhythm Female Humans Hypertension / physiopathology* Male Middle Aged Sodium / administration & dosage* Statistics as Topic |
| Grant Support | |
ID/Acronym/Agency:
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RR-01346/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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