Document Detail


Salt sensitivity, endogenous ouabain and hypertension.
MedLine Citation:
PMID:  23207724     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Endogenous cardiotonic steroids (CTS) exert long-term effects on salt and blood pressure homeostasis. Here we discuss recent observations on mechanisms of salt sensitivity that involve endogenous ouabain and novel pathways in the brain and discuss their possible relationship to arterial and renal function in hypertension.
RECENT FINDINGS: Chronic elevation of brain sodium promotes sustained hypertension mediated by central endogenous ouabain and the Na(+) pump α-2 catalytic subunit. The intermediary pressor mechanism in the brain involves aldosterone biosynthesis, activation of mineralocorticoid receptors and increased epithelial sodium channel activity. In the periphery, elevated plasma CTS raise contractility and blood pressure by augmentation of sympathetic nerve responses, increasing arterial Ca(2+) signaling and blunting nitric oxide production in the renal medulla and collecting ducts.
SUMMARY: Endogenous ouabain in the brain appears to play a critical role in salt sensitivity and hypertension. In the periphery, the J-shaped relationship of plasma endogenous ouabain in response to short-term changes in salt balance in humans raises the possibility that endogenous ouabain contributes to the increased risk of adverse cardiovascular events associated with both low and high salt intakes.
Authors:
John M Hamlyn; Mordecai P Blaustein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  22     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-04     Completed Date:  2013-06-03     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  51-8     Citation Subset:  IM    
Affiliation:
Department of Physiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA. jhamlyn@umaryland.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Brain / metabolism
Homeostasis / physiology*
Humans
Hypertension / metabolism*,  physiopathology
Ouabain / metabolism*
Sodium Chloride / adverse effects,  metabolism*
Grant Support
ID/Acronym/Agency:
HL045215/HL/NHLBI NIH HHS; HL10755/HL/NHLBI NIH HHS; R01 HL045215/HL/NHLBI NIH HHS; R01 HL107555/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
630-60-4/Ouabain; 7647-14-5/Sodium Chloride
Comments/Corrections

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