| Salt restriction and increased insulin production in hypertensive patients. | |
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MedLine Citation:
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PMID: 7997846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was performed to evaluate glucose metabolism, serum lipids and sympathetic activity during 12 weeks of a moderate salt restricted diet in hypertensive patients. The study was designed as a pre-test-post-test study. All patients from a controlled trial evaluating self-monitoring of urine chloride concentration as a remedy for enhancing diet compliance and blood pressure effect were included. Twenty male patients and 14 female patients with essential hypertension (mean age 53 years) were randomized to a self monitoring diet group and a diet only group. They were exposed to a moderately salt restricted diet during 12 weeks. Fasting serum insulin C-peptide, glucose, HbA1c, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were measured along with 24 h urine excretion of adrenaline, noradrenaline and vanillylmandelic acid (VMA). As a result, insulin C-peptide increased by 40% (p = 0.0001) whereas glucose rose by 6% (p = 0.02). Total cholesterol, LDL-cholesterol and HDL-cholesterol concentration were reduced by 6% (p = 0.001), 12% (p = 0.008) and 11% (p = 0.004) respectively. HbA1c, serum triglycerides, total/HDL-cholesterol ratio, urine catecholamines and VMA were unchanged during the trial. It is concluded that salt restriction may increase insulin resistance in hypertensive patients. |
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Authors:
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E Meland; E Laerum; A Aakvaag; R J Ulvik |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 54 ISSN: 0036-5513 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1995-01-13 Completed Date: 1995-01-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: NORWAY |
Other Details:
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Languages: eng Pagination: 405-9 Citation Subset: IM |
Affiliation:
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Department of Public Health and Primary Health Care, Division for General Practice, Bergen, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Glucose / metabolism* Diet, Sodium-Restricted* Evaluation Studies as Topic Female Humans Hypertension / diet therapy*, metabolism Insulin / biosynthesis* Lipids / blood* Male Middle Aged Self Care Sympathetic Nervous System / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Lipids; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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