Document Detail

Salt-leached silk scaffolds with tunable mechanical properties.
MedLine Citation:
PMID:  23016499     Owner:  NLM     Status:  MEDLINE    
Substrate mechanical properties have remarkable influences on cell behavior and tissue regeneration. Although salt-leached silk scaffolds have been used in tissue engineering, applications in softer tissue regeneration can be encumbered with excessive stiffness. In the present study, silk-bound water interactions were regulated by controlling processing to allow the preparation of salt-leached porous scaffolds with tunable mechanical properties. Increasing silk-bound water interactions resulted in reduced silk II (β-sheet crystal) formation during salt-leaching, which resulted in a modulus decrease in the scaffolds. The microstructures as well as degradation behavior were also changed, implying that this water control and salt-leaching approach can be used to achieve tunable mechanical properties. Considering the utility of silk in various fields of biomedicine, the results point to a new approach to generate silk scaffolds with controllable properties to better mimic soft tissues by combining scaffold preparation methods and silk self-assembly in aqueous solutions.
Danyu Yao; Sen Dong; Qiang Lu; Xiao Hu; David L Kaplan; Bingbo Zhang; Hesun Zhu
Related Documents :
21881899 - Ecological assessment of french atlantic lakes based on phytoplankton, phytobenthos and...
22097029 - The study of adsorption characteristics of electrospun polymer nanofibers for benzenes ...
18311309 - Dual-mode surface-plasmon-resonance sensors using angular interrogation.
19322469 - Enantioselective crystallization on nanochiral surfaces.
1191479 - Surface anaesthetic properties of the new local anaesthetic amid etidocaine (duranest):...
24817579 - Endospore surface properties of commonly used bacillus anthracis surrogates vary in aqu...
10419679 - Temperature dependence of bubble nucleation limits for aqueous solutions of carbon diox...
22004659 - Moving through the phase diagram: morphology formation in solution cast polymer-fullere...
21663539 - Stimuli-responsive liposome-nanoparticle assemblies.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-11
Journal Detail:
Title:  Biomacromolecules     Volume:  13     ISSN:  1526-4602     ISO Abbreviation:  Biomacromolecules     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-06-05     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3723-9     Citation Subset:  IM    
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biocompatible Materials / chemistry*
Silk / chemistry*
Sodium Chloride
Tissue Engineering*
Tissue Scaffolds*
Grant Support
Reg. No./Substance:
0/Biocompatible Materials; 0/Silk; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  TOCCATA: a customized carbon total correlation spectroscopy NMR metabolomics database.
Next Document:  Comment on "308 nm Photolysis of Nitric Acid in the Gas Phase, on Aluminum Surfaces, and on Ice Film...