Document Detail

Salt-leached silk scaffolds with tunable mechanical properties.
MedLine Citation:
PMID:  23016499     Owner:  NLM     Status:  MEDLINE    
Substrate mechanical properties have remarkable influences on cell behavior and tissue regeneration. Although salt-leached silk scaffolds have been used in tissue engineering, applications in softer tissue regeneration can be encumbered with excessive stiffness. In the present study, silk-bound water interactions were regulated by controlling processing to allow the preparation of salt-leached porous scaffolds with tunable mechanical properties. Increasing silk-bound water interactions resulted in reduced silk II (β-sheet crystal) formation during salt-leaching, which resulted in a modulus decrease in the scaffolds. The microstructures as well as degradation behavior were also changed, implying that this water control and salt-leaching approach can be used to achieve tunable mechanical properties. Considering the utility of silk in various fields of biomedicine, the results point to a new approach to generate silk scaffolds with controllable properties to better mimic soft tissues by combining scaffold preparation methods and silk self-assembly in aqueous solutions.
Danyu Yao; Sen Dong; Qiang Lu; Xiao Hu; David L Kaplan; Bingbo Zhang; Hesun Zhu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-11
Journal Detail:
Title:  Biomacromolecules     Volume:  13     ISSN:  1526-4602     ISO Abbreviation:  Biomacromolecules     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-06-05     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3723-9     Citation Subset:  IM    
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, People's Republic of China.
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MeSH Terms
Biocompatible Materials / chemistry*
Silk / chemistry*
Sodium Chloride
Tissue Engineering*
Tissue Scaffolds*
Grant Support
Reg. No./Substance:
0/Biocompatible Materials; 0/Silk; 7647-14-5/Sodium Chloride

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