Document Detail

Salt intake and risk of gastric intestinal metaplasia: systematic review and meta-analysis.
MedLine Citation:
PMID:  20099187     Owner:  NLM     Status:  MEDLINE    
The understanding of the association between salt intake and precancerous lesions may contribute to clarify the causal relation with gastric cancer. We systematically reviewed 17 articles addressing the association between dietary salt exposure and gastric intestinal metaplasia and conducted meta-analyses for quantitative synthesis (random effects model). Salt exposure was estimated assessing salted/salty food consumption, preference for salted/salty foods, use of table salt, or sodium urinary excretion. Heterogeneity was also large regarding food items evaluated, consumption categories, and data analysis. The combined odds ratio (OR) was 1.68 (95% confidence interval (CI) = 0.98-2.90; I(2) = 55.4%) for the association between salted/salty meat and intestinal metaplasia (4 studies) and the OR was 1.53 (95% CI = 0.72-3.24; I(2) = 76.8%) for salt preference. There was a positive, nonstatistically significant association between intestinal metaplasia and urinary sodium excretion. The heterogeneity of methodological options and results preclude quantitative synthesis or its proper interpretation, even if the available evidence may suggest a positive association between salt and intestinal metaplasia.
Marina Dias-Neto; Mariana Pintalhao; Mariana Ferreira; Nuno Lunet
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nutrition and cancer     Volume:  62     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-25     Completed Date:  2010-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  133-47     Citation Subset:  IM    
Porto University Medical School and Institute of Public Health-University of Porto (ISPUP), 4200-319 Porto, Portugal.
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MeSH Terms
Aged, 80 and over
Food Preferences
Intestines / pathology*
Middle Aged
Odds Ratio
Precancerous Conditions / chemically induced
Sodium Chloride, Dietary / administration & dosage*,  adverse effects*
Stomach / pathology*
Stomach Neoplasms / chemically induced
Reg. No./Substance:
0/Sodium Chloride, Dietary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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