Document Detail

Salt intake and hypertension therapy.
MedLine Citation:
PMID:  11936420     Owner:  NLM     Status:  MEDLINE    
Hypertension is a risk factor for cardiovascular and renal organ damage. Environmental conditions affect the development of high blood pressure (BP), although genetic influences are also important. Current international guidelines recommend reducing dietary sodium to no more than 100 mmol (about 2.4 g sodium or approximately 6 g salt) per day to prevent BP rising; the current intake of sodium in industrialized countries is approximately double the recommended amount. Clinical trials (DASH and TOHP studies) have shown that dietary factors are fundamental in the prevention and control of BP. Low dietary sodium intake is particularly effective in preventing hypertension in subjects with an increased risk such as the overweight, borderline hypertensives or the elderly. A low-salt diet combined with anti-hypertensive therapies facilitates BP reduction independent of race. The hypotensive effect of calcium channel blockers is less dependent on salt intake than other drugs, such as ACE inhibitors or diuretics. Reduced sodium intake associated with other dietary changes (such as weight loss, and increasing potassium, calcium and magnesium intake) are important instruments for the prevention and therapy of hypertension.
Alberto Milan; Paolo Mulatero; Franco Rabbia; Franco Veglio
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of nephrology     Volume:  15     ISSN:  1121-8428     ISO Abbreviation:  J. Nephrol.     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-04-08     Completed Date:  2002-11-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Department of Medicine and Experimental Oncology, University of Turin, Italy.
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MeSH Terms
Blood Pressure / drug effects
Calcium Channel Blockers / therapeutic use
Captopril / therapeutic use
Diuretics / therapeutic use*
Hypertension / etiology,  prevention & control,  therapy*
Renin-Angiotensin System / drug effects
Risk Factors
Sodium, Dietary / administration & dosage*,  adverse effects
Weight Loss
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Diuretics; 0/Sodium, Dietary; 62571-86-2/Captopril

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