Document Detail


Salt and hypertension--future directions.
MedLine Citation:
PMID:  1987005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The comments that follow reflect the personal views of this author regarding some useful directions of research in the field of salt and hypertension. From a physiological perspective, salt sensitivity is defined, and the merits and limitations of certain animal models of hypertension used to study this issue are discussed. The need to more clearly define the mechanisms that detect sodium intake and control the renal excretion of sodium is discussed. Additionally, the need to better understand the relation between sodium homeostasis, volume regulation, and the consequences of dysfunction in these regulatory system on the arterial vasculature and interstitial matrix is emphasized. The necessity for the application of new tools and approaches in a number of investigative areas is discussed. Finally, the necessity of equally imaginative whole animal and cell/molecular research and efforts to merge and integrate the data obtained at the cellular level with that of intact systems is emphasized.
Authors:
A W Cowley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  17     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-02-19     Completed Date:  1991-02-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I205-10     Citation Subset:  IM; S    
Affiliation:
Medical College of Wisconsin, Department of Physiology, Milwaukee 53226.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Blood Pressure / drug effects
Blood Vessels / drug effects
Blood Volume
Central Nervous System / physiology
Disease Models, Animal
Extracellular Space / physiology
Forecasting
Humans
Hypertension / chemically induced*
Ions
Mechanoreceptors / physiology
Molecular Biology / methods
Natriuresis
Research
Sodium Chloride* / metabolism,  pharmacology
Chemical
Reg. No./Substance:
0/Ions; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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