Document Detail

Salt consumption and cardiovascular, renal, and hypertensive diseases: clinical and mechanistic aspects.
MedLine Citation:
PMID:  22123673     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review will discuss some relevant and novel studies on the relationship between sodium intake and cardiovascular structure and function, focusing on blood pressure independent effects of salt on the heart, arteries, and kidneys.
RECENT FINDINGS: Several new reports clearly demonstrate the role of high dietary salt in mediating cardiovascular and renal morbidity and mortality including stroke, myocardial infarction, arterial stiffening, heart failure, and renal insufficiency. A number of recent studies also indicate that in addition to increased sodium intake, simultaneous decrease in potassium intake may aggravate adverse cardiovascular and renal manifestations.
SUMMARY: It is now generally accepted that there is a direct positive correlation between dietary salt and arterial pressure. Thus, the beneficial effects of dietary salt reduction are, at least in part, due to a decrease in arterial pressure. Furthermore, the beneficial, pressure-independent effects of sodium restriction on the heart, blood vessels, and kidneys are being increasingly recognized, but not generally appreciated.
Dinko Susic; Edward D Frohlich
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in lipidology     Volume:  23     ISSN:  1473-6535     ISO Abbreviation:  Curr. Opin. Lipidol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-05-14     Revised Date:  2012-06-21    
Medline Journal Info:
Nlm Unique ID:  9010000     Medline TA:  Curr Opin Lipidol     Country:  England    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana, USA.
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MeSH Terms
Blood Pressure
Cardiovascular Diseases / etiology*,  physiopathology
Kidney Diseases / etiology*,  physiopathology
Nutritional Requirements
Sodium Chloride, Dietary / adverse effects*
Reg. No./Substance:
0/Sodium Chloride, Dietary
Comment In:
Curr Opin Lipidol. 2012 Jun;23(3):256-7   [PMID:  22576584 ]

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