Document Detail

Salt Loading Promotes Kidney Injury via Fibrosis in Young Female Ren2 Rats.
MedLine Citation:
PMID:  24847333     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND/AIMS: It is increasingly recognized that there is sexual dimorphism in kidney disease progression; however, this disparity is lost in the presence of diabetes where women progress at a similar rate to men. The renin-angiotensin-aldosterone system (RAAS) is known to regulate diabetes-induced kidney injury, and recent literature would suggest that gender differences exist in RAAS-dependent responses in the kidney. In this regard, these gender differences may be overcome by excessive salt intake. Thereby, we hypothesized that salt would promote proteinuria in transgenic female rats under conditions of excess tissue angiotensin (Ang) II and circulating aldosterone.
MATERIALS AND METHODS: We utilized young female transgenic (mRen2)27 (Ren2) rats and Sprague-Dawley (SD) littermates and fed a high-salt diet (4%) over 3 weeks.
RESULTS: Compared to SD and Ren2 controls, female Ren2 rats fed a high-salt diet displayed increases in proteinuria, periarterial and interstitial fibrosis as well as ultrastructural evidence of basement membrane thickening, loss of mitochondrial elongation, mitochondrial fragmentation and attenuation of basilar canalicular infoldings. These findings occurred temporally with increases in transforming growth factor-β but not indices of oxidant stress.
CONCLUSIONS: Our current data suggest that a diet high in salt promotes progressive kidney injury as measured by proteinuria and fibrosis associated with transforming growth factor-β under conditions of excess tissue Ang II and circulating aldosterone.
Javad Habibi; Melvin R Hayden; Carlos M Ferrario; James R Sowers; Adam T Whaley-Connell
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Publication Detail:
Type:  Journal Article     Date:  2014-03-14
Journal Detail:
Title:  Cardiorenal medicine     Volume:  4     ISSN:  1664-3828     ISO Abbreviation:  Cardiorenal Med     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-05-21     Completed Date:  2014-05-21     Revised Date:  2014-05-26    
Medline Journal Info:
Nlm Unique ID:  101554863     Medline TA:  Cardiorenal Med     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  43-52     Citation Subset:  -    
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