Document Detail


Salsolinol, catecholamine metabolites, and visual hallucinations in L-dopa treated patients with Parkinson's disease.
MedLine Citation:
PMID:  9617786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We could quantify the tetrahydroisoquinoline derivative salsolinol in urine of patients with Parkinson's disease and normal control subjects by means of high performance liquid chromatography and electrochemical detection. Urine levels of salsolinol were positively related to the homovanillic acid/3-O-methyl-dopa ratio in the cerebrospinal fluid that reflects dopamine metabolism. In the patient group with visual hallucinations, mean salsolinol level was significantly increased to almost the 3-fold of those found in patients without hallucinations. Since the daily L-dopa doses of both patient groups were nearly identical this result is not due to different L-dopa medications. Additionally, either high values of the main serotonin metabolite, 5-hydroxyindole acetic acid (HIAA) or the L-dopa/3-O-methyl-dopa ratio were found in cerebrospinal fluid of patients with hallucinations. The enhanced salsolinol levels in patients with visual hallucinations seem to be due to an overloaded dopaminergic pathway with an imbalance between dopaminergic and serotonergic systems. Thus, salsolinol appears as a predictor for hallucinosis in Parkinson's disease.
Authors:
A Moser; F Siebecker; P Vieregge; P Jaskowski; D Kömpf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  103     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  1996  
Date Detail:
Created Date:  1998-07-28     Completed Date:  1998-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  421-32     Citation Subset:  IM    
Affiliation:
Department of Neurology, Medical University, Lübeck, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Antiparkinson Agents / therapeutic use*
Biological Markers / cerebrospinal fluid,  urine
Catecholamines / cerebrospinal fluid*
Female
Hallucinations / complications*,  urine
Homovanillic Acid / cerebrospinal fluid
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid
Isoquinolines / urine*
Levodopa / therapeutic use*
Male
Parkinson Disease / drug therapy,  metabolism*,  psychology*
Reference Values
Regression Analysis
Tyrosine / analogs & derivatives,  cerebrospinal fluid
Chemical
Reg. No./Substance:
0/Antiparkinson Agents; 0/Biological Markers; 0/Catecholamines; 0/Isoquinolines; 0/Levodopa; 306-08-1/Homovanillic Acid; 525-72-4/salsolinol; 54-16-0/Hydroxyindoleacetic Acid; 55520-40-6/Tyrosine; 7636-26-2/3-methoxytyrosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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