| Salsolinol, catecholamine metabolites, and visual hallucinations in L-dopa treated patients with Parkinson's disease. | |
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MedLine Citation:
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PMID: 9617786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We could quantify the tetrahydroisoquinoline derivative salsolinol in urine of patients with Parkinson's disease and normal control subjects by means of high performance liquid chromatography and electrochemical detection. Urine levels of salsolinol were positively related to the homovanillic acid/3-O-methyl-dopa ratio in the cerebrospinal fluid that reflects dopamine metabolism. In the patient group with visual hallucinations, mean salsolinol level was significantly increased to almost the 3-fold of those found in patients without hallucinations. Since the daily L-dopa doses of both patient groups were nearly identical this result is not due to different L-dopa medications. Additionally, either high values of the main serotonin metabolite, 5-hydroxyindole acetic acid (HIAA) or the L-dopa/3-O-methyl-dopa ratio were found in cerebrospinal fluid of patients with hallucinations. The enhanced salsolinol levels in patients with visual hallucinations seem to be due to an overloaded dopaminergic pathway with an imbalance between dopaminergic and serotonergic systems. Thus, salsolinol appears as a predictor for hallucinosis in Parkinson's disease. |
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Authors:
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A Moser; F Siebecker; P Vieregge; P Jaskowski; D Kömpf |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neural transmission (Vienna, Austria : 1996) Volume: 103 ISSN: 0300-9564 ISO Abbreviation: J Neural Transm Publication Date: 1996 |
Date Detail:
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Created Date: 1998-07-28 Completed Date: 1998-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9702341 Medline TA: J Neural Transm Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 421-32 Citation Subset: IM |
Affiliation:
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Department of Neurology, Medical University, Lübeck, Federal Republic of Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Antiparkinson Agents / therapeutic use* Biological Markers / cerebrospinal fluid, urine Catecholamines / cerebrospinal fluid* Female Hallucinations / complications*, urine Homovanillic Acid / cerebrospinal fluid Humans Hydroxyindoleacetic Acid / cerebrospinal fluid Isoquinolines / urine* Levodopa / therapeutic use* Male Parkinson Disease / drug therapy, metabolism*, psychology* Reference Values Regression Analysis Tyrosine / analogs & derivatives, cerebrospinal fluid |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Biological Markers; 0/Catecholamines; 0/Isoquinolines; 0/Levodopa; 306-08-1/Homovanillic Acid; 525-72-4/salsolinol; 54-16-0/Hydroxyindoleacetic Acid; 55520-40-6/Tyrosine; 7636-26-2/3-methoxytyrosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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