Document Detail


Salmonella stress management and its relevance to behaviour during intestinal colonisation and infection.
MedLine Citation:
PMID:  16023758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The enteric pathogen Salmonella enterica is exposed to a number of stressful environments during its life cycle within and outside its various hosts. During intestinal colonisation Salmonella is successively exposed to acid pH in the stomach, to the detergent-like activity of bile, to decreasing oxygen supply, to the presence of multiple metabolites produced by the normal gut microflora and finally it is exposed to cationic antimicrobial peptides present on the surface of epithelial cells. There are four major regulators controlling relevant stress responses in Salmonella, namely RpoS, PhoPQ, Fur and OmpR/EnvZ. Except for Fur, inactivation of genes encoding the other stress regulators results in attenuated virulence and such mutants can therefore be considered as vaccine candidates. In contrast, a decrease in oxygen supply monitored by Fnr and ArcAB, or oxidative stress controlled by OxyR and SoxRS is not regarded as a stress associated with host colonisation since inactivation of either of these systems does not result in reductions in colonisation. The role of quorum-sensing through luxS and sdiA is also considered as a regulator of virulence and colonisation.
Authors:
Ivan Rychlik; Paul A Barrow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-06-29
Journal Detail:
Title:  FEMS microbiology reviews     Volume:  29     ISSN:  0168-6445     ISO Abbreviation:  FEMS Microbiol. Rev.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-12     Completed Date:  2005-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8902526     Medline TA:  FEMS Microbiol Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1021-40     Citation Subset:  IM    
Affiliation:
Veterinary Research Institute, Hudcova 70, 621 32 Brno, Czech Republic. rychlik@vri.cz
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Proteins / genetics,  metabolism
Gene Expression Regulation, Bacterial*
Heat-Shock Response*
Humans
Hydrogen-Ion Concentration
Intestines / microbiology*
Salmonella Infections / microbiology*
Salmonella enteritidis / growth & development,  pathogenicity,  physiology*
Salmonella typhimurium / growth & development,  pathogenicity,  physiology*
Virulence
Chemical
Reg. No./Substance:
0/Bacterial Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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