Document Detail

Salmonella enterica shedding in hospitalized horses and associations with diarrhea occurrence among their stablemates and gastrointestinal-related illness or death following discharge.
MedLine Citation:
PMID:  22380811     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the potential association between Salmonella enterica shedding in hospitalized horses and the risk of diarrhea among stablemates, and to characterize gastrointestinal-related illness and death following discharge among horses that shed S. enterica while hospitalized.
DESIGN: Retrospective cohort study [corrected].
ANIMALS: 221 horses (59 that shed S. enterica during hospitalization and 162 that tested negative for S. enterica shedding ≥ 3 times during hospitalization).
PROCEDURES: Information from medical records (signalment, results of microbial culture of fecal samples, clinical status at the time of culture, and treatment history) was combined with data collected through interviews with horse owners regarding formerly hospitalized horses and their stablemates. Data were analyzed to investigate risk factors for death and diarrhea.
RESULTS: Occurrence of diarrhea among stablemates of formerly hospitalized horses was not associated with S. enterica shedding in hospitalized horses but was associated with oral treatment with antimicrobials during hospitalization. Salmonella enterica shedding during hospitalization was not associated with risk of death or gastrointestinal-related illness in study horses ≤ 6 months after discharge, but shedding status and history of gastrointestinal illness were associated with increased risk of death during the preinterview period.
CONCLUSIONS AND CLINICAL RELEVANCE: Stablemates of horses that shed S. enterica during hospitalization did not appear to have an increased risk for diarrhea, but comingling with horses that receive orally administered antimicrobials may affect this risk. Salmonella enterica shedding during hospitalization may be a marker of increased long-term risk of death after discharge. Risks are likely influenced by the S enterica strain involved and biosecurity procedures used.
Amanda K Hartnack; David C Van Metre; Paul S Morley
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  240     ISSN:  1943-569X     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-02     Completed Date:  2012-07-09     Revised Date:  2014-05-29    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  726-33     Citation Subset:  IM    
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MeSH Terms
Bacterial Shedding / physiology*
Case-Control Studies
Gastrointestinal Diseases / microbiology,  mortality,  veterinary*
Horse Diseases / microbiology*,  mortality,  transmission
Retrospective Studies
Salmonella Infections, Animal / microbiology*,  pathology,  transmission
Salmonella enterica / physiology*
Erratum In:
J Am Vet Med Assoc. 2012 Apr 1;240(7):868

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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