Document Detail

Salmonella enterica serovar Typhimurium lipopolysaccharide deacylation enhances its intracellular growth within macrophages.
MedLine Citation:
PMID:  19932105     Owner:  NLM     Status:  MEDLINE    
Modification of lipid A is essential for bacterial adaptation to its host. Salmonella Typhimurium LpxR potentially detoxifies lipid A by 3'-O-deacylation; however, the involvement of deacylation in its adaptation remains unclear. LpxR-dependent 3'-O-deacylation was observed in the stationary phase. When macrophages were infected with stationary phase bacteria, the intracellular growth of the lpxR-null strain was lower than that of the wild-type strain. Furthermore, the expression level of inducible nitric oxide synthase was higher in the cells infected with the lpxR-null strain than in the cells infected with the wild-type strain. These results indicate that lipid A 3'-O-deacylation is beneficial for intracellular growth.
Miyuki Kawano; Takayuki Manabe; Kiyoshi Kawasaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  584     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Doshisha Women's College, Kodo, Kyotanabe, Kyoto, Japan.
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MeSH Terms
Carboxylic Ester Hydrolases / genetics,  metabolism*
Cell Line
Lipid A / metabolism*
Macrophages / microbiology*
Salmonella typhimurium / enzymology,  genetics,  growth & development*
Reg. No./Substance:
0/Lipid A; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.-/LpxR protein, Salmonella typhimurium

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