Document Detail


Salmon thrombin-fibrinogen dressing allows greater survival and preserves distal blood flow compared to standard kaolin gauze in coagulopathic Swine with a standardized lethal femoral artery injury.
MedLine Citation:
PMID:  22707021     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We have previously shown that lyophilized salmon thrombin and fibrinogen (STF) embedded in a dissolvable dextran dressing is as efficacious as Combat Gauze (CG) with regard to controlling hemorrhage and survival in non-coagulopathic swine with femoral artery lacerations. A major limitation of currently available advanced field dressings is the inability to control hemorrhage in coagulopathic casualties because of the exhaustion of host coagulation proteins. We tested the hypothesis that the STF dressing would be better able to control hemorrhage and prolong survival in coagulopathic swine compared to CG. Survival rate was 50% in CG-treated animals versus 90% in STF-treated animals. Survival time was significantly greater in STF-treated animals. Clots formed over the arterial injury in 100% of STF-treated animals compared to 0% in CG-treated animals (p < 0.001). STF-treated animals consumed less host coagulation factors, including platelets (p = 0.03). Survival after limb manipulation that simulated casualty evacuation was significantly higher with the STF dressing (p < 0.005). Angiographic observation of distal blood flow was seen twice as often with the STF dressing as with CG. The STF dressing allows a high survival rate, significantly greater survival time, and a significantly more stable dressing than CG in coagulopathic swine. The clot formed by the STF dressing also enables restoration of distal blood flow to the limb potentially resulting in higher limb salvage.
Authors:
C Timothy Floyd; Stephen W Rothwell; Jack Risdahl; Roy Martin; Curtis Olson; Nate Rose
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of special operations medicine : a peer reviewed journal for SOF medical professionals     Volume:  12     ISSN:  1553-9768     ISO Abbreviation:  J Spec Oper Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158402     Medline TA:  J Spec Oper Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-26     Citation Subset:  IM    
Copyright Information:
2012.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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