| Salmon stanniocalcin and bovine parathyroid hormone have dissimilar actions on mammalian bone. | |
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MedLine Citation:
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PMID: 1666805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stanniocalcin (STC), a calcium-regulating glycoprotein hormone isolated from the corpuscles of Stannius of salmon, was tested for effects on bone and calcium metabolism in mammalian species (rats and mice). STC generally failed to alter serum calcium of parathyroidectomized rats at concentrations equimolar with effective concentrations of parathyroid hormone (PTH). STC did not increase cAMP in ROS 17/2.8 or UMR-108 osteosarcoma cells, OK kidney cells, fetal rat limb bones, or neonatal mouse calvariae, and similarly failed to increase urinary cAMP in rats. STC did not consistently stimulate resorption in any of the rodent bone culture systems, although variable resorptive responses were elicited in fetal mouse calvariae. The results indicate that this fish hormone has limited, if any, PTH-like activity on calcium metabolism in mammalian systems. |
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Authors:
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P H Stern; G Shankar; R C Fargher; D H Copp; C E Milliken; K J Sato; D Goltzman; M P Herrmann-Erlee |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Volume: 6 ISSN: 0884-0431 ISO Abbreviation: J. Bone Miner. Res. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-05-04 Completed Date: 1992-05-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8610640 Medline TA: J Bone Miner Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1153-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Resorption Bone and Bones / drug effects* Calcium / blood Cattle Cell Line Cyclic AMP / analysis Glycoproteins / pharmacology* Hormones* Kinetics Mice Organ Culture Techniques Parathyroid Hormone / pharmacology* Rats Rats, Inbred Strains Salmon Tumor Cells, Cultured |
| Grant Support | |
ID/Acronym/Agency:
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AR 11262/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Hormones; 0/Parathyroid Hormone; 60-92-4/Cyclic AMP; 7440-70-2/Calcium; 76687-96-2/teleocalcin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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