| Salivary-soluble CD44 levels in smokers and non-smokers with chronic periodontitis: a pilot study. | |
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MedLine Citation:
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PMID: 20429650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Smoking is the most important environmental risk factor for periodontal disease. Elevated levels of serum-soluble CD44 (sCD44) have been detected in smokers and also have been recognized as a diagnostic marker in some smoking-induced diseases. The present study investigates the salivary sCD44 profiles of smokers and non-smokers with and without chronic periodontitis in response to scaling and root planing (SRP). METHODS: The study included 44 subjects divided into two groups: 22 patients with chronic periodontitis and 22 periodontally healthy subjects. Both groups were equally subdivided into smokers (n = 11) and non-smokers (n = 11). Plaque index, gingival index, probing depth, and clinical attachment level were recorded only for chronic periodontitis patients. Salivary samples were collected from all 44 patients at baseline and after 1 month of SRP from the 22 chronic periodontitis patients. Assay for salivary sCD44 was carried out by enzyme-linked immunosorbent assay. RESULTS: Baseline salivary sCD44 profiles were significantly higher when smokers were compared to non-smokers in both chronic periodontitis patients and the control subjects (P <0.001) with the highest levels recorded in smokers within the chronic periodontitis group. There was a significant decline in salivary sCD44 levels after treatment in the chronic periodontitis group for both smokers and non-smokers (P <0.01); however, the difference between groups was insignificant. CONCLUSIONS: Salivary sCD44 might be considered a biomarker of periodontal destruction in smokers and non-smokers. The research opens the door to further research into a role for CD44 as a diagnostic marker for periodontitis. |
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Authors:
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Noha Ghallab; Olfat Shaker |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of periodontology Volume: 81 ISSN: 1943-3670 ISO Abbreviation: J. Periodontol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-30 Completed Date: 2010-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: United States |
Other Details:
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Languages: eng Pagination: 710-7 Citation Subset: D; IM |
Affiliation:
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Department of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD44 / analysis* Biological Markers / analysis Chronic Periodontitis / classification, metabolism*, therapy Dental Plaque Index Dental Scaling Female Follow-Up Studies Gingival Hemorrhage / classification Humans Male Middle Aged Periodontal Attachment Loss / classification Periodontal Index Periodontal Pocket / classification Pilot Projects Root Planing Salivary Proteins and Peptides / analysis* Smoking / metabolism* Subgingival Curettage |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD44; 0/Biological Markers; 0/CD44 protein, human; 0/Salivary Proteins and Peptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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