Document Detail

Salivary and serum interleukin 6 and basic fibroblast growth factor levels in patients with oral squamous cell carcinoma.
MedLine Citation:
PMID:  16224376     Owner:  NLM     Status:  MEDLINE    
AIM: A role of various cytokines has been implicated in the pathogenesis of many carcinomas, and albeit the role of interleukin 6 (IL-6) and basic fibroblast growth factor (bFGF) in sera has been studied in patients with oral carcinomas, data upon salivary IL-6 and bFGF are lacking. The aim of this study was to evaluate levels of IL-6 and bFGF in the saliva and serum of patients with oral squamous cell carcinoma. METHODS: Salivary and serum IL-6 and bFGF were evaluated in a group of 33 patients (28 men, 5 women) with oral squamous cell carcinoma (OSCC), age range 40-73 years , mean 54.05 years. Control group consisted of 23 healhy participants, mean age 25 years. RESULTS: Serum IL-6 and bFGF levels were not significantly different between patients with OSCC and healthy controls. Elevated levels of salivary IL-6 and bFGF in patients with OSCC when compared to the healthy controls were found (p<0.001). CONCLUSIONS: The conclusion is drawn that higher levels of salivary IL-6 and bFGF in patients with OSCC might originate from the local production, probably from carcinoma cells.
V Vucicević Boras; N Cikes; J Lukać; M Virag; A Cekić-Arambasin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Minerva stomatologica     Volume:  54     ISSN:  0026-4970     ISO Abbreviation:  Minerva Stomatol     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-14     Completed Date:  2006-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421071     Medline TA:  Minerva Stomatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  569-73     Citation Subset:  D; IM    
Department of Oral medicine, School of Dental Medicine, University of Zagreb Zagreb, Croatia.
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MeSH Terms
Carcinoma, Squamous Cell / immunology*
Fibroblast Growth Factor 2 / analysis*,  blood
Interleukin-6 / analysis*,  blood
Middle Aged
Mouth Neoplasms / immunology*
Saliva / chemistry*
Reg. No./Substance:
0/Interleukin-6; 103107-01-3/Fibroblast Growth Factor 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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