| Salivary proteins and cytokines in drug-induced gingival overgrowth. | |
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MedLine Citation:
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PMID: 15044507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Little is known about the involvement of saliva in gingival overgrowth (GO). It was hypothesized that, in this situation, the composition of saliva is altered. Thus, proteins, albumin, cytokines, and growth factors in whole and glandular saliva were investigated. Differences between glandular and gingival contributions to the composition of saliva were explored in patients medicated with cyclosporin who exhibited GO (responders), those without GO (non-responders), and non-medicated subjects (controls). In whole saliva, interleukin-1alpha (IL-1alpha), IL-6, IL-8, epidermal growth factor (EGF), nerve growth factor (NGF), and albumin were detected, but in glandular saliva only EGF and NGF were identified. Albumin and IL-6 differed significantly between responders and controls, although the overall profile of salivary proteins remained unchanged. Thus, inflammatory cytokines and albumin are confined to whole saliva and are associated with GO, whereas its content of EGF and NGF appears unaffected by cyclosporin. |
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Authors:
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S Ruhl; S Hamberger; R Betz; T Sukkar; G Schmalz; R A Seymour; K-A Hiller; J M Thomason |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of dental research Volume: 83 ISSN: 0022-0345 ISO Abbreviation: J. Dent. Res. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-26 Completed Date: 2004-05-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: United States |
Other Details:
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Languages: eng Pagination: 322-6 Citation Subset: D; IM |
Affiliation:
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Department of Operative Dentistry and Periodontology, Dental School, University of Regensburg, 93042 Regensburg, Germany. stefan.ruhl@klinik.uni-regensburg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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analysis,
metabolism* Cyclosporine Cytokines / analysis, metabolism* Epidermal Growth Factor / analysis, metabolism Gingival Overgrowth / chemically induced, metabolism* Humans Interleukins / analysis, metabolism Male Nerve Growth Factor / analysis, metabolism Saliva / chemistry, metabolism* Salivary Proteins and Peptides / analysis, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Cytokines; 0/Interleukins; 0/Salivary Proteins and Peptides; 59865-13-3/Cyclosporine; 62229-50-9/Epidermal Growth Factor; 9061-61-4/Nerve Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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