Document Detail


Salivary paracetamol elimination in patients with congestive cardiac failure.
MedLine Citation:
PMID:  3442954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Salivary paracetamol elimination was studied in nine patients with congestive cardiac failure (CCF). Six healthy volunteers served as the control group. 2. Paracetamol elimination t1/2 and apparent volume of distribution were significantly higher in patients with CCF compared with controls. There was no significant change in the clearance rate. 3. Drug therapy of failure for a period of 15 days returned the t1/2 and V values to normality.
Authors:
N P Kumar; K R Sethuraman; S Chandrasekar; K Ray; C Adithan; C H Shashindran
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  14     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1988-05-05     Completed Date:  1988-05-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  731-4     Citation Subset:  IM    
Affiliation:
Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / pharmacokinetics*
Adult
Half-Life
Heart Failure / metabolism*
Humans
Male
Saliva / metabolism*
Chemical
Reg. No./Substance:
103-90-2/Acetaminophen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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