| Salivary paracetamol elimination in patients with congestive cardiac failure. | |
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MedLine Citation:
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PMID: 3442954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Salivary paracetamol elimination was studied in nine patients with congestive cardiac failure (CCF). Six healthy volunteers served as the control group. 2. Paracetamol elimination t1/2 and apparent volume of distribution were significantly higher in patients with CCF compared with controls. There was no significant change in the clearance rate. 3. Drug therapy of failure for a period of 15 days returned the t1/2 and V values to normality. |
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Authors:
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N P Kumar; K R Sethuraman; S Chandrasekar; K Ray; C Adithan; C H Shashindran |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 14 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1987 Sep |
Date Detail:
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Created Date: 1988-05-05 Completed Date: 1988-05-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 731-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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pharmacokinetics* Adult Half-Life Heart Failure / metabolism* Humans Male Saliva / metabolism* |
| Chemical | |
Reg. No./Substance:
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103-90-2/Acetaminophen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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