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Salivary markers of oxidative stress and their relation to periodontal and dental status in children.
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MedLine Citation:
PMID:  23151614     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous studies have shown that salivary thiobarbituric acid reactive substances are related to the periodontal status in adults. Such an analysis has not been done on children yet. The aim of our study was to analyze salivary markers of oxidative stress in relation to periodontal and dental status in children.
METHODS: The periodontal and dental status of 82 consecutive pediatric dental patients was assessed. The oral hygiene index (OHI), the papillary bleeding index (PBI) and the caries index (CI) were assessed as clinical parameters. Markers of oxidative stress and antioxidant status were measured in whole saliva samples.
RESULTS: Multivariate analysis of covariance showed that the variability of PBI explains 10.9% of the variance of salivary thiobarbituric acid reacting substances (TBARS). Advanced oxidation protein products (AOPP) were related to CI (eta 8.6%). Measures of antioxidant status (total antioxidant capacity and ferric reducing ability of saliva) were partially determined by OHI (13.6% and 7.2%) and PBI (16.9% and 7.9%).
CONCLUSIONS: Antioxidant status in saliva is related to oral hygiene and periodontal status. Salivary TBARS are a potential sensitive marker of periodontitis in children, similarly to adults, at least on a population level. Salivary AOPP are related to caries. Potential diagnostic value of the analyzed markers should be analyzed in further interventional studies.
L'ubomíra Tóthová; Viera Celecová; Peter Celec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Disease markers     Volume:  34     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2013  
Date Detail:
Created Date:  2012-12-18     Completed Date:  2013-05-28     Revised Date:  2013-12-30    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
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MeSH Terms
Advanced Oxidation Protein Products / metabolism
Antioxidants / metabolism
Biological Markers / metabolism
Cross-Sectional Studies
Dental Caries / metabolism
Glycosylation End Products, Advanced / metabolism
Multivariate Analysis
Oxidative Stress*
Periodontitis / metabolism
Saliva / metabolism*
Thiobarbituric Acid Reactive Substances / metabolism
Reg. No./Substance:
0/Advanced Oxidation Protein Products; 0/Antioxidants; 0/Biological Markers; 0/Glycosylation End Products, Advanced; 0/Thiobarbituric Acid Reactive Substances

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2013 Hindawi Publishing Corporation.
Received Day: 12 Month: 11 Year: 2012
Accepted Day: 12 Month: 11 Year: 2012
Print publication date: Year: 2013
Electronic publication date: Day: 17 Month: 12 Year: 2012
Volume: 34 Issue: 1
First Page: 9 Last Page: 15
PubMed Id: 23151614
ID: 3809743
Article Id: 591765
DOI: 10.3233/DMA-2012-00943

Salivary Markers of Oxidative Stress and Their Relation to Periodontal and Dental Status in Children
L’ubomíra Tóthová1
Viera Celecová2
Peter Celec134*
1Institute of Molecular BiomedicineComenius UniversityBratislavaSlovakia
2Private Stomatological PraxisKrupinaSlovakia
3Department of Molecular BiologyComenius UniversityBratislavaSlovakia
4Institute of PathophysiologyComenius UniversityBratislavaSlovakia
Correspondence: *Peter Celec:

Article Categories:
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Keywords: Salivary TBARS, oxidative stress, saliva, periodontal status, dental caries.

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