Document Detail

Salivary levels of Tumour Necrosis Factor-alpha in patients with recurrent aphthous stomatitis.
MedLine Citation:
PMID:  20711148     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Recurrent aphthous stomatitis (RAS) is a common pathology of the oral mucosa with a complex and multifactorial etiology. Tumour Necrosis Factor-alpha (TNFα) is a cytokine with an important but not well-known role in the development of new lesions in RAS patients. Modifications of salivary levels of TNFα in RAS patients during the active periods of the disease have been measured in this work. The possible implication of TNFα in RAS etiology is also discussed.
STUDY DESIGN: The study group was composed of 20 patients previously diagnosed with RAS and randomly selected. As a control group 10 healthy patients were also randomly selected. In both groups a TNFα assessment was carried out in non stimulated saliva. All the patients in the study group presented active lesions at the moment of the salivary sample collection. Values oscillating between 0 and 8.1 pg/ml were considered as normal.
RESULTS: Salivary TNFα levels are 2 to 5 times higher in RAS patients than those of healthy patients.
CONCLUSIONS: TNFα has a possible implication in the RAS etiology and it may also have an important role in the search of new treatments for this disease.
Asier Eguia-del Valle; Rafael Martinez-Conde-Llamosas; Jose López-Vicente; Agurne Uribarri-Etxebarria; José-Manuel Aguirre-Urizar
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Publication Detail:
Type:  Journal Article     Date:  2011-01-01
Journal Detail:
Title:  Medicina oral, patología oral y cirugía bucal     Volume:  16     ISSN:  1698-6946     ISO Abbreviation:  Med Oral Patol Oral Cir Bucal     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-30     Completed Date:  2011-05-03     Revised Date:  2012-11-09    
Medline Journal Info:
Nlm Unique ID:  101231694     Medline TA:  Med Oral Patol Oral Cir Bucal     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  e33-6     Citation Subset:  D; IM    
Oral Medicine, Faculty of Medicine and Dentistry, University of the Basque Country, Spain.
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MeSH Terms
Saliva / chemistry*
Stomatitis, Aphthous* / etiology
Tumor Necrosis Factor-alpha / analysis*
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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