Document Detail


Salivary immunoglobulin A antibodies to gp41 in human immunodeficiency virus-seropositive patients: lack of correlation with disease progression.
MedLine Citation:
PMID:  11358543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mucous membranes are the main route of transmission of human immunodeficiency virus (HIV). Interestingly, some viral inhibitory activities have been found in saliva. The purpose of this study was to determine the level of salivary immunoglobulin A (IgA) antibodies to gp41 in HIV+ patients at various disease stages to identify whether gp41 was able to induce vigorous humoral responses. Unstimulated saliva samples were obtained from three groups of subjects (n=37): group A (HIV-), group B (HIV+, CD4+ <200/mm3), and group C (HIV+, CD4+ >200/mm3). IgA antibody levels to purified gp41 were determined by enzyme-linked immunosorbent assay (ELISA). Western blot analyses were performed using HIV+ saliva to confirm IgA reactivity to gp41. ELISA demonstrated that HIV+ subjects had higher IgA antibody to gp41 than HIV- individuals. No significant differences were noted between HIV+, CD4+ <200/mm3 and CD4+ >200/mm3 subjects. High (81.25%) IgA reactivity to gp41 was demonstrated by Western blotting of saliva from all HIV+ individuals. In conclusion, gp41 responses are important in the HIV disease process, as indicated by the high IgA levels and gp41 reactivity in saliva of HIV+ patients.
Authors:
M J Toro; L Escalona; P Chaiyarit; N A Warner; R L Gregory
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Oral microbiology and immunology     Volume:  16     ISSN:  0902-0055     ISO Abbreviation:  Oral Microbiol. Immunol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-18     Completed Date:  2001-08-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8707451     Medline TA:  Oral Microbiol Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  188-92     Citation Subset:  D    
Affiliation:
Department of Oral Biology, School of Dentistry, Indiana University, Indianapolis, IN 46202, USA.
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / classification,  immunology
Adult
Analysis of Variance
Antibodies, Viral / analysis*
Antibody Formation / immunology
Blotting, Western
CD4 Lymphocyte Count
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
HIV Envelope Protein gp41 / immunology*
HIV Infections / classification,  immunology
HIV Seronegativity
HIV Seropositivity / immunology*
Humans
Immunoglobulin A, Secretory / analysis*
Male
Saliva / immunology*
Grant Support
ID/Acronym/Agency:
DE0349/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/HIV Envelope Protein gp41; 0/Immunoglobulin A, Secretory

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