Document Detail

Salivary gland toxicity after radioiodine therapy for thyroid cancer.
MedLine Citation:
PMID:  17305259     Owner:  NLM     Status:  MEDLINE    
AIMS: Salivary gland toxicity is a common, but not widely appreciated, adverse effect of high-dose radioiodine (131I). This study was carried out to determine the incidence of symptoms of salivary gland damage after 131I treatment for differentiated thyroid cancer. MATERIALS AND METHODS: This was a prospective study of 76 consecutive patients attending thyroid cancer treatment. Symptoms of salivary gland damage (dry mouth, pain and swelling) were assessed during hospital admission and at follow-up visits. Additionally, a retrospective analysis was carried out of patients recorded in our database as having chronic salivary gland swelling after 131I ablation. RESULTS: Twenty patients (26%) developed salivary gland toxicity, 11 (15%) had symptoms within the first 48 h, continuing for 12 months in seven of these patients. The onset of toxicity in a further nine (12%) patients with persistent symptoms did not occur until 3 months after therapy. In total, 16 (21%) patients had evidence of chronic toxicity, typically xerostomia, at 12 months. Toxicity was more common after repeated 131I administration. After searching our thyroid cancer database, we identified an additional five patients to have chronic salivary gland swelling (chronic sialadenitis or pleomorphic adenoma) 20 months to 23 years after 131I. CONCLUSIONS: Pain, swelling and dry mouth occurred frequently after 131I, with some developing symptoms months or years after administration. Early recognition of salivary gland complications may help to reduce morbidity in these patients.
S Hyer; A Kong; B Pratt; C Harmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical oncology (Royal College of Radiologists (Great Britain))     Volume:  19     ISSN:  0936-6555     ISO Abbreviation:  Clin Oncol (R Coll Radiol)     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-19     Completed Date:  2007-03-20     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9002902     Medline TA:  Clin Oncol (R Coll Radiol)     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
Thyroid Unit, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK.
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MeSH Terms
Adenoma / radiography*
Adenoma, Oxyphilic / radiotherapy
Aged, 80 and over
Iodine Radioisotopes / adverse effects
Middle Aged
Prospective Studies
Radiation Injuries / etiology*
Radiotherapy Dosage
Retrospective Studies
Salivary Glands / radiation effects*
Thyroid Neoplasms / radiotherapy*
Treatment Outcome
Xerostomia / etiology
Reg. No./Substance:
0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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