| Salivary gland function in persons with ectodermal dysplasias. | |
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MedLine Citation:
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PMID: 12974678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ectodermal dysplasias (EDs) constitute a group of conditions comprising developmental defects in two or more of the following tissues: hair, teeth, nails, and sweat glands. The aim of the present study was to contribute to a better understanding of salivary gland involvement in EDs. An ED group (n = 39, median age 12 yr; 24 males, 15 females) and a healthy age- and sex-matched control group were studied. Citric acid stimulated submandibular and parotid salivary flow rates and salivary concentrations, and output of total protein, acidic proline-rich proteins and histatins were analysed. The associations between quantitative and qualitative salivary parameters were also studied. In the ED group, 13 persons (33%) demonstrated a significantly reduced secretion of submandibular and/or parotid saliva, in addition to a low unstimulated and/or chewing-stimulated whole salivary flow. In the ED group as a whole, a reduced median secretory rate of submandibular saliva was found, whereas the median concentrations of some protein parameters were increased. However, the overall output of proteins was normal or reduced. Submandibular glands seemed to be more affected than parotid glands in EDs. In conclusion, salivary secretory tests are recommended in persons with known or suspected EDs. |
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Authors:
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Hilde Nordgarden; Kari Storhaug; Staale Petter Lyngstadaas; Janicke Liaaen Jensen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of oral sciences Volume: 111 ISSN: 0909-8836 ISO Abbreviation: Eur. J. Oral Sci. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-16 Completed Date: 2003-12-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9504563 Medline TA: Eur J Oral Sci Country: Denmark |
Other Details:
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Languages: eng Pagination: 371-6 Citation Subset: D; IM |
Affiliation:
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Department of Oral Surgery and Oral Medicine, Institute of Clinical Dentistry, Oslo, Norway. hilde.nordgaren@tako.dep.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Case-Control Studies Child Child, Preschool Ectodermal Dysplasia / physiopathology* Female Humans Male Middle Aged Parotid Gland / physiopathology* Peptides / analysis Proline / analysis Proline-Rich Protein Domains Proteins / analysis Saliva / secretion Salivary Proteins and Peptides / analysis Secretory Rate / physiology Statistics, Nonparametric Submandibular Gland / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 0/Proteins; 0/Salivary Proteins and Peptides; 0/histidine-rich proteins; 147-85-3/Proline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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