| Salivary function in patients with chronic renal failure undergoing hemodialysis. | |
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MedLine Citation:
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PMID: 12043905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to evaluate the changes in salivary gland function in patients with chronic renal failure (CRF) undergoing hemodialysis. METHODS: The group consisted of 23 patients with CRF (13 female, 10 male; mean age: 40 +/- 13 yr) and 14 healthy control subjects (mean age: 40 +/- 13 yr). All underwent dynamic salivary gland scintigraphy with gustatory stimulation. After intravenous administration of 99mTc pertechnetate, first, perfusion images at 2 seconds per frame were acquired for 1 minute, then dynamic images at 1 minute per frame were acquired for 45 minutes. At 30 minutes after injection, 10 ml lemon juice was given for 15 minutes as a gustatory stimulus. We obtained time-activity curves derived from regions of interest centered over the four major salivary glands. The following functional indices were calculated for each gland: the time of maximum radioactivity (Tmax) for the prestimulated period, the time of minimum radioactivity (Tmin), as an indicator of velocity of secretion after stimulation, and the Lem E5% value as an indicator of the secretion function. RESULTS: When the patients with CRF undergoing hemodialysis were compared to the controls, there were statistically significant differences in Tmax, Tmin and Lem E5% values for bilateral parotid glands, and Tmin values for bilateral submandibular glands (p < 0.05), there were no statistically significant differences in Tmax and Lem E5% values for bilateral submandibular glands. There were also significant differences in Tmax and Lem E5% values for bilateral parotid glands between mild oral problems and severe oral problems in patients with CRF (undergoing hemodialysis). CONCLUSION: In this study, prolonged Tmax and Tmin values, and decreased Lem E5% values for parotid glands and prolonged Tmin values for submandibular glands on salivary scintigraphy pointed out decreased parenchymatous and excretory function in patients with CRF undergoing hemodialysis. |
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Authors:
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Meryem Kaya; Tevfik Fikret Cermik; Funda Ustün; Saniye Sen; Sakir Berkarda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 16 ISSN: 0914-7187 ISO Abbreviation: Ann Nucl Med Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-06-04 Completed Date: 2002-12-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 117-20 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Trakya University Medical Faculty, Edirne, Turkey. meryemk@trakya.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Case-Control Studies Female Humans Kidney Failure, Chronic / physiopathology*, radionuclide imaging*, therapy Male Middle Aged Radiopharmaceuticals / diagnostic use Renal Dialysis Salivary Glands / physiopathology*, radionuclide imaging* Sodium Pertechnetate Tc 99m / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 23288-60-0/Sodium Pertechnetate Tc 99m |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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