| Salivary excretion of 5-fluorouracil (5-FU). V. Effect of 5-FU concentration in perfusate on the salivary excretion of 5-FU in perfused rat mandibular gland. | |
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MedLine Citation:
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PMID: 2268905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of 5-fluorouracil (5-FU) concentration in the perfusate on the salivary excretion of 5-FU was investigated in the rat mandibular gland perfused with modified Ringer solution containing pilocarpine (10 microM). The saliva to venous-effluent concentration ratio (S/E ratio) of 5-FU increased gradually during the perfusion. The 5-FU concentration in the perfusate ranging from 10 to 200 micrograms/ml caused elevation in the mean value of S/E ratio. This non-linearity suggested that the present perfusion method would be useful to further investigation for the mechanism of salivary excretion of 5-FU, since the tendency of the non-linearity was similar to that in in vivo studies as reported previously. The salivary flow rate declined with time, and the greater mean value of the flow rate was obtained during perfusion with the perfusate containing the lower level of 5-FU. Statistically significant correlation was found between the S/E ratio of 5-FU and salivary flow rate (p less than 0.01). Therefore, in the perfused rat mandibular gland, it was concluded that 5-FU itself had an influence on the salivary excretion of 5-FU via decreasing salivary flow rate. On the other hand, the salivary clearance of 5-FU showed no distinct increase and/or decrease not only with time but also with the change of 5-FU concentration in the perfusate. It seems to result from the cancellation of the increased S/E ratio of 5-FU by the decreased salivary flow rate in perfused rat mandibular gland. |
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Authors:
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Y Hayashi; J Watanabe |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 38 ISSN: 0009-2363 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1991-02-20 Completed Date: 1991-02-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 2008-11 Citation Subset: IM |
Affiliation:
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Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fluorouracil / pharmacokinetics* Male Perfusion Rats Rats, Inbred Strains Saliva / metabolism* Submandibular Gland / metabolism* |
| Chemical | |
Reg. No./Substance:
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51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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