| Salivary enzymes and periodontal disease. | |
| | |
MedLine Citation:
|
PMID: 16505786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Host responses to periodontal disease include the production of different enzymes that are released by stromal, epithelial or inflammatory cells. There are important enzymes associated with cell injury and cell death like: aspartate and alanine aminotransferase (AST, ALT), lactate dehydrogenase (LDH), creatine kinase (CK), alkaline and acidic phosphatase (ALP, ACP), gama glutamyl transferase (GGT). Changes in enzymatic activity reflect metabolic changes in the gingiva and periodontium in inflammation. DESIGN OF STUDY: In this paper we have examined the activity of CK, LDH, AST, ALT, GGT, ALP and ACP in saliva from patients with periodontal disease before and after periodontal treatment (experimental group, 30 samples) and in saliva from healthy patients (control group--20 samples). Periodontal disease was determined based on clinical parameters (gingival index (GI), bleeding on probing (BOP), probing depth (PD)). Patients with periodontal disease were under conventional periodontal treatment. RESULTS: Obtained results were shown statistically significant increases of activity of CK, LDH, AST, ALT, GGT, ALP, ACP in saliva from patients with periodontal disease in relation to control group. There is positive correlation between the activity of examined salivary enzymes and value of the gingival index. After conventional periodontal therapy the activity of all salivary enzymes was significantly decreased. CONCLUSIONS: Based on these results, it can be assume that activity of these enzymes in saliva, as biochemical markers for periodontal tissue damage, may be useful in diagnosis, prognosis and evaluation of therapy effects in periodontal disease. |
| | |
Authors:
|
Tatjana Todorovic; Ivan Dozic; Mario Vicente-Barrero; Besir Ljuskovic; Janko Pejovic; Marjan Marjanovic; Milan Knezevic |
Publication Detail:
|
Type: Journal Article Date: 2006-03-01 |
Journal Detail:
|
Title: Medicina oral, patología oral y cirugía bucal Volume: 11 ISSN: 1698-6946 ISO Abbreviation: Med Oral Patol Oral Cir Bucal Publication Date: 2006 Mar |
Date Detail:
|
Created Date: 2006-02-28 Completed Date: 2006-07-13 Revised Date: 2009-12-11 |
Medline Journal Info:
|
Nlm Unique ID: 101231694 Medline TA: Med Oral Patol Oral Cir Bucal Country: Spain |
Other Details:
|
Languages: eng; spa Pagination: E115-9 Citation Subset: D; IM |
Affiliation:
|
Departamento de Bioquímica, Facultad de Estomatología, Universidad de Belgrado, Serbia and Montenegro. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Enzymes / analysis Female Humans Male Middle Aged Periodontal Diseases / enzymology* Saliva / chemistry, enzymology* |
| Chemical | |
Reg. No./Substance:
|
0/Enzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Progressive Hemifacial Atrophy--case report.
Next Document: Effect of the high molecular weight chitosan and sodium alginate on Candida albicans hydrophobicity ...