Document Detail

Salivary endothelin and vascular disorders in vibration-exposed workers.
MedLine Citation:
PMID:  18493696     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study investigated the relation between salivary endothelin, vibration exposure, and vascular disorders in a group of forestry workers. METHODS: Altogether 54 forestry workers and 52 controls underwent a medical examination and a cold test with measurement of the percentage of change in finger systolic blood pressure after finger cooling from 30 degrees C to 10 degrees C (FSBP% (10 degrees)). Salivary endothelin concentration (ET(1-21), in fmol/ml) was measured by a commercially available enzyme-linked immunosorbent assay before and after the cold challenge. The anamnestic diagnosis of vibration-induced white finger (VWF), assisted by color charts, was based on the Stockholm Workshop criteria. RESULTS: Six forestry workers (11%) and one control (2%) reported white fingers. Before the cold challenge, the salivary ET(1-21) concentration was significantly greater in the VWF workers than in the controls (P=0.036). The cold response of digital arteries was stronger in the VWF workers than in the controls (P<0.001) and the asymptomatic forestry workers (P=0.008). After the cold test, there was a small, not significant, increase in the salivary ET(1-21) concentration in both the controls and the forestry workers. For the latter, the salivary ET(1-21) concentration was significantly associated with both daily and total operating time with vibrating tools. A significant inverse relation between FSBP% (10 degrees )and the salivary ET(1-21) concentration was observed for the forestry workers with an abnormal cold response in their digital arteries. CONCLUSIONS: This study showed an association between salivary ET(1-21) concentration, daily and cumulative vibration exposure, and vascular disorders in the fingers of professional forestry workers. Since ET(1-21) can induce powerful and long-lasting constriction of human vessels, these findings suggest a possible role of this vasopeptide in the pathogenesis of VWF.
Massimo Bovenzi; Flavia D'Agostin; Francesca Rui; Luigi Ambrosi; Roberto Zefferino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  34     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-21     Completed Date:  2008-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  Finland    
Other Details:
Languages:  eng     Pagination:  133-41     Citation Subset:  IM    
Clinical Unit of Occupational Medicine, Department of Public Health Sciences, University of Trieste, Centro Tumori, Via della Pietà 19, Trieste, Italy.
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MeSH Terms
Biological Markers / metabolism
Case-Control Studies
Cross-Sectional Studies
Endothelins / metabolism*
Hand-Arm Vibration Syndrome / epidemiology,  metabolism*,  prevention & control
Italy / epidemiology
Linear Models
Multivariate Analysis
Occupational Diseases / epidemiology,  metabolism*,  prevention & control
Reg. No./Substance:
0/Biological Markers; 0/Endothelins

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