| Salivary cooling, escape reaction and heat pain in capsaicin-desensitized rats. | |
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MedLine Citation:
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PMID: 575415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Salivary thermolytic mechanisms (weight of salivary glands, effect of desalivation on water intake and body temperature, grooming activity) as well as escape behaviour and reaction to heat pain were studied in capsaicin-desensitized and control rats exposed to various warm ambient temperatures. Body temperature of the desensitized rats increased more than the controls' at all the ambient temperatures studied (32, 34 and 36 degrees C); however, significant differences in the mechanism of salivary cooling were obtained only at 34 and 36 degrees C. Central impairment of saliva spreading in desensitized rats seems evident. Complete surgical desalivation did not increase hyperthermia of control and desensitized animals in warm environments. Therefore other mechanisms, primarily vasodilatatory, must also be involved in the rat's thermolytic normal response. Although desensitized rats did not show a tendency to escape from the warm environment their response to heat pain was normal. In conclusion, it is suggested that heat perception in desensitized animals is impaired; however, the existence of some capsaicin-insensitive thermolytic mechanisms (prone extension of the body) cannot be excluded. |
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Authors:
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F Obál; G Benedek; A Jancsó-Gábor; F Obál |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 382 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1979 Nov |
Date Detail:
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Created Date: 1980-05-23 Completed Date: 1980-05-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 249-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects Body Temperature Regulation / drug effects* Capsaicin / adverse effects* Escape Reaction / physiology Fatty Acids, Unsaturated / adverse effects* Grooming / physiology Hot Temperature Male Pain / physiology Rats Salivary Glands / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; 404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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