| Salivary chemokine levels in patients with primary Sjogren's syndrome. | |
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MedLine Citation:
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PMID: 20525739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The present study aimed to investigate the salivary chemokine levels in patients with primary SS (pSS) and compare them with those in patients with non-SS sicca symptoms or non-sicca controls. METHODS: Unstimulated and stimulated whole saliva samples were obtained from pSS patients (n = 30) and age- and gender-matched patients with non-SS sicca (n = 30) and non-sicca healthy controls (n = 25). Salivary CCL2, CCL3, CCL4, CXCL8 and CXCL10 levels were measured using a Luminex bead-based multiplex assay. RESULTS: Patients with pSS had significantly different distributions of salivary CCL3 (P = 0.0001 by the Kruskal-Wallis test), CCL4 (P < 0.00001), CXLC8 (P < 0.0001) and CXCL10 (P < 0.05) levels in unstimulated saliva and all chemokine levels in stimulated saliva when compared with non-SS sicca and non-sicca controls. In comparison with chemokine production rate, the CXCL8 and CXCL10 production rates were significantly higher in pSS than in non-SS sicca controls (P < 0.01 by the Mann-Whitney test). Logistic regression analyses revealed that salivary CXCL8 (P < 0.05) and CXCL10 (P < 0.05) were the significant discriminating chemokines between the pSS and non-SS sicca groups. Although CXCL8 and CXCL10 levels were not correlated with the focus scores, CXCL8 and CXCL10 levels were significantly associated with salivary gland dysfunction. CONCLUSION: These results support the notion that CXCL8 or CXCL10 chemokine plays a role in the pathogenesis of pSS. |
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Authors:
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Yun Jong Lee; Robert H Scofield; Joon Young Hyon; Pil-Young Yun; Hyo-Jung Lee; Eun Young Lee; Eun Bong Lee; Yeong Wook Song |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-04 |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: 49 ISSN: 1462-0332 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2011-03-11 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: England |
Other Details:
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Languages: eng Pagination: 1747-52 Citation Subset: AIM; IM |
Affiliation:
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Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Chemokine CXCL10 / diagnostic use, metabolism Chemokines / diagnostic use*, metabolism Female Humans Interleukin-8 / diagnostic use, metabolism Male Middle Aged Predictive Value of Tests Saliva / metabolism* Salivary Glands / metabolism* Sjogren's Syndrome / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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DE017561/DE/NIDCR NIH HHS; P30 AR053483/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CXCL10; 0/Chemokines; 0/Interleukin-8 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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