Document Detail


Salivary chemokine levels in patients with primary Sjogren's syndrome.
MedLine Citation:
PMID:  20525739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The present study aimed to investigate the salivary chemokine levels in patients with primary SS (pSS) and compare them with those in patients with non-SS sicca symptoms or non-sicca controls.
METHODS: Unstimulated and stimulated whole saliva samples were obtained from pSS patients (n = 30) and age- and gender-matched patients with non-SS sicca (n = 30) and non-sicca healthy controls (n = 25). Salivary CCL2, CCL3, CCL4, CXCL8 and CXCL10 levels were measured using a Luminex bead-based multiplex assay.
RESULTS: Patients with pSS had significantly different distributions of salivary CCL3 (P = 0.0001 by the Kruskal-Wallis test), CCL4 (P < 0.00001), CXLC8 (P < 0.0001) and CXCL10 (P < 0.05) levels in unstimulated saliva and all chemokine levels in stimulated saliva when compared with non-SS sicca and non-sicca controls. In comparison with chemokine production rate, the CXCL8 and CXCL10 production rates were significantly higher in pSS than in non-SS sicca controls (P < 0.01 by the Mann-Whitney test). Logistic regression analyses revealed that salivary CXCL8 (P < 0.05) and CXCL10 (P < 0.05) were the significant discriminating chemokines between the pSS and non-SS sicca groups. Although CXCL8 and CXCL10 levels were not correlated with the focus scores, CXCL8 and CXCL10 levels were significantly associated with salivary gland dysfunction.
CONCLUSION: These results support the notion that CXCL8 or CXCL10 chemokine plays a role in the pathogenesis of pSS.
Authors:
Yun Jong Lee; Robert H Scofield; Joon Young Hyon; Pil-Young Yun; Hyo-Jung Lee; Eun Young Lee; Eun Bong Lee; Yeong Wook Song
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-06-04
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  49     ISSN:  1462-0332     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-11     Completed Date:  2011-03-11     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1747-52     Citation Subset:  AIM; IM    
Affiliation:
Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Case-Control Studies
Chemokine CXCL10 / diagnostic use,  metabolism
Chemokines / diagnostic use*,  metabolism
Female
Humans
Interleukin-8 / diagnostic use,  metabolism
Male
Middle Aged
Predictive Value of Tests
Saliva / metabolism*
Salivary Glands / metabolism*
Sjogren's Syndrome / physiopathology*
Grant Support
ID/Acronym/Agency:
DE017561/DE/NIDCR NIH HHS; P30 AR053483/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Chemokine CXCL10; 0/Chemokines; 0/Interleukin-8
Comments/Corrections

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