Document Detail


Salivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model.
MedLine Citation:
PMID:  23021916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis.
METHODS: Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation, and tissue remodeling using immunosorbent assays. Levels were compared with baseline and levels observed in 97 healthy controls.
RESULTS: Biomarkers of myocardial damage and inflammation (ie, troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2- to 812-fold after ASA (P < .01). Significant elevations of 2.0- to 3.5-fold were observed with C-reactive protein and troponin I in saliva (P < .02). Significant correlations between levels in serum and saliva were observed for C-reactive protein, matrix metalloproteinase-9, and myeloperoxidase (P < .001).
CONCLUSIONS: Select salivary biomarkers reflect changes that occur during, and subsequent to, myocardial necrosis caused by ASA.
Authors:
Joseph D Foley; J Darrell Sneed; Steven R Steinhubl; Justin R Kolasa; Jeffrey L Ebersole; Yushun Lin; Richard J Kryscio; John T McDevitt; Charles L Campbell; Craig S Miller
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-09-28
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology and oral radiology     Volume:  114     ISSN:  2212-4411     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-06-05     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101576782     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  616-23     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Internal Medicine, Division of Cardiovascular Medicine, College of Medicine, University of Kentucky, and Lexington Veterans Administration Hospital, Lexington, Kentucky, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / analysis*,  blood
Cardiomyopathies / diagnosis*
Cardiomyopathy, Hypertrophic / drug therapy*
Case-Control Studies
Ethanol / administration & dosage*,  therapeutic use
Female
Heart Septum / drug effects*
Humans
Male
Middle Aged
Necrosis
Saliva / chemistry*
Grant Support
ID/Acronym/Agency:
M01-RR02602/RR/NCRR NIH HHS; P20 RR020145/RR/NCRR NIH HHS; P20 RR020145/RR/NCRR NIH HHS; U01 DE017793/DE/NIDCR NIH HHS; U01 DE017793/DE/NIDCR NIH HHS; UL1RR033173/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 64-17-5/Ethanol
Comments/Corrections

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