Document Detail


Salivary beta2-microglobulin analysis in chronic kidney disease and hemodialyzed patients.
MedLine Citation:
PMID:  18187941     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Beta2-microglobulin (beta2m) is a major component in dialysis-related amyloidosis, a disabling disease affecting long-term dialysis patients. METHODS: Beta2m and other components were analyzed in saliva and serum from 53 individuals in 4 subgroups: healthy normal controls, diabetes mellitus (DM), chronic kidney disease (CKD) and hemodialysis (HD) patients. RESULTS: Median salivary and mean serum beta2m concentrations were 78% higher in both saliva (p = 0.048) and serum (p = 0.047) in DM patients; 118% (p = 0.016) and 907% (p = 0.007) higher, respectively, in CKD patients, and 328% (p = 0.0001) and 2,710% (p = 0.001) higher, respectively, in HD patients, compared with healthy controls. The correlation analysis between salivary and serum beta2m concentrations showed a low correlation rate in HD patients (r = -0.18), but was rather high in CKD patients (r = 0.50). CONCLUSIONS: Salivary analysis of beta2m is a reliable method for evaluating serum beta2m levels in CKD patients, and may help predict the potential for development of CKD-induced amyloidosis.
Authors:
Regina Michelis; Shifra Sela; Ilan Ben-Zvi; Rafael M Nagler
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-01-11
Journal Detail:
Title:  Blood purification     Volume:  25     ISSN:  1421-9735     ISO Abbreviation:  Blood Purif.     Publication Date:  2007  
Date Detail:
Created Date:  2008-01-30     Completed Date:  2008-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  505-9     Citation Subset:  IM    
Copyright Information:
2008 S. Karger AG, Basel
Affiliation:
Eliachar Research Laboratory, Western Galilee Hospital, Nahariya, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Amyloidosis / diagnosis
Case-Control Studies
Diabetes Mellitus
Female
Humans
Kidney Failure, Chronic / complications*,  therapy
Male
Middle Aged
Renal Dialysis*
Saliva / chemistry*
beta 2-Microglobulin / analysis*,  blood
Chemical
Reg. No./Substance:
0/beta 2-Microglobulin

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