| Salivary beta2-microglobulin analysis in chronic kidney disease and hemodialyzed patients. | |
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MedLine Citation:
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PMID: 18187941 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Beta2-microglobulin (beta2m) is a major component in dialysis-related amyloidosis, a disabling disease affecting long-term dialysis patients. METHODS: Beta2m and other components were analyzed in saliva and serum from 53 individuals in 4 subgroups: healthy normal controls, diabetes mellitus (DM), chronic kidney disease (CKD) and hemodialysis (HD) patients. RESULTS: Median salivary and mean serum beta2m concentrations were 78% higher in both saliva (p = 0.048) and serum (p = 0.047) in DM patients; 118% (p = 0.016) and 907% (p = 0.007) higher, respectively, in CKD patients, and 328% (p = 0.0001) and 2,710% (p = 0.001) higher, respectively, in HD patients, compared with healthy controls. The correlation analysis between salivary and serum beta2m concentrations showed a low correlation rate in HD patients (r = -0.18), but was rather high in CKD patients (r = 0.50). CONCLUSIONS: Salivary analysis of beta2m is a reliable method for evaluating serum beta2m levels in CKD patients, and may help predict the potential for development of CKD-induced amyloidosis. |
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Authors:
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Regina Michelis; Shifra Sela; Ilan Ben-Zvi; Rafael M Nagler |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-01-11 |
Journal Detail:
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Title: Blood purification Volume: 25 ISSN: 1421-9735 ISO Abbreviation: Blood Purif. Publication Date: 2007 |
Date Detail:
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Created Date: 2008-01-30 Completed Date: 2008-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: Switzerland |
Other Details:
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Languages: eng Pagination: 505-9 Citation Subset: IM |
Copyright Information:
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2008 S. Karger AG, Basel |
Affiliation:
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Eliachar Research Laboratory, Western Galilee Hospital, Nahariya, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Amyloidosis / diagnosis Case-Control Studies Diabetes Mellitus Female Humans Kidney Failure, Chronic / complications*, therapy Male Middle Aged Renal Dialysis* Saliva / chemistry* beta 2-Microglobulin / analysis*, blood |
| Chemical | |
Reg. No./Substance:
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0/beta 2-Microglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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