Document Detail


Salivary basic fibroblast growth factor in patients with oral squamous cell carcinoma or oral lichen planus.
MedLine Citation:
PMID:  22769407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of this study was to gather preliminary data concerning the feasibility of using salivary basic fibroblast growth factor (bFGF) for detecting development of oral squamous cell carcinoma (OSCC) in patients with oral lichen planus (OLP), and in patients with OSCC whose disease was in remission.
STUDY DESIGN: Saliva samples were collected from 5 patient groups: patients with newly diagnosed OSCC, patients with OSCC whose disease was in remission, patients with OLP in disease-active state, patients with OLP in disease-inactive state, and healthy controls. Salivary bFGF levels were determined by enzyme-linked immunosorbent assay, and data were analyzed using the Mann-Whitney U test.
RESULTS: Salivary bFGF levels were significantly elevated in patients with newly diagnosed OSCC compared with patients with OSCC in remission, patients with disease-active OLP, and healthy controls. No significant difference was found between patients with newly diagnosed OSCC and patients with disease-inactive OLP.
CONCLUSIONS: Our results suggested that salivary bFGF might be a potential biomarker for detecting OSCC development in patients with OSCC in remission, but not in patients with OLP.
Authors:
Lakshmi Mitreyi Gorugantula; Terry Rees; Jacqueline Plemons; Huey-Shys Chen; Yi-Shing Lisa Cheng
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology and oral radiology     Volume:  114     ISSN:  2212-4411     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-09     Completed Date:  2013-04-15     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  101576782     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / diagnosis,  metabolism*
Case-Control Studies
Feasibility Studies
Female
Fibroblast Growth Factor 2 / analysis*
Humans
Lichen Planus, Oral / diagnosis,  metabolism*
Male
Middle Aged
Mouth Neoplasms / diagnosis,  metabolism*
Neoplasm Recurrence, Local / diagnosis,  metabolism
Neoplasm Regression, Spontaneous
Saliva / chemistry*
Sample Size
Statistics, Nonparametric
Grant Support
ID/Acronym/Agency:
1R21DE018757-01A2/DE/NIDCR NIH HHS; R21 DE018757/DE/NIDCR NIH HHS; R21 DE018757-01A2/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
103107-01-3/Fibroblast Growth Factor 2
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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