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Salivary Interleukin-1Beta Levels in Chronic Periodontitis Patients Before and After Periodontal Phase-I Therapy and Healthy Controls - A Case-Control Study.
MedLine Citation:
PMID:  21235331     Owner:  NLM     Status:  Publisher    
Background: The role of interleukin-1beta (IL-1β) in periodontal disease pathogenesis is well researched. This study aimed to assess and compare the salivary IL-1β levels in chronic periodontitis patients, before and after periodontal phase-I therapy and periodontally healthy controls. Further, relationships between IL-1β levels and various clinical parameters were explored. Materials and Methods: Twenty-eight moderate to severe generalized chronic periodontitis patients and 24 age, race and ethnicity matched controls participated in the study. Saliva samples were obtained from all subjects. The clinical parameters recorded were: clinical attachment loss (CAL), probing pocket depth (PPD), bleeding on probing (BOP), periodontal index (PI) and gingival index (GI). Clinical evaluation and sample collection was repeated 1month post periodontal phase-I therapy, in periodontitis patients. IL-1β levels were assessed using enzyme linked immunosorbent assay (ELISA). Results: Mean IL-1β levels in periodontitis patients at baseline (1312.75 pg/ml) were significantly higher (P <0.001; 8 fold) than in controls (161.51 pg/ml). Although, treatment in periodontitis patients resulted in significant reduction in IL-1β levels (mean: 674.34 pg/ml; P = 0.001), they remained significantly higher (P <0.001; 4 fold) than control levels. There were significant correlations between IL-1β levels and all clinical parameters (P <0.01), except percentage sites with CAL >2mm (P >0.05). Conclusion: The data indicate that IL-1β levels are raised in the saliva of chronic periodontitis patients, which reduces post phase-I therapy, suggesting a close association between salivary IL-1β and periodontitis. Additional longitudinal studies are needed to validate salivary IL-1β as a marker for periodontal disease.
Rachna Kaushik; R K Yeltiwar; Kumar Pushpanshu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-14
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
MDS, Department of Periodontics, Rungta College of Dental Sciences & Research, Bhilai, India.
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