Document Detail


Salivary IgA responses to prolonged intensive exercise following caffeine ingestion.
MedLine Citation:
PMID:  16540839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Prolonged, intensive exercise is associated with a reduction in concentration and secretion of salivary IgA (s-IgA). Saliva composition and secretion are under autonomic nervous system control, and caffeine ingestion, a widespread practice among athletes for its ergogenic properties, is associated with increased sympathetic nervous system activation. Therefore, this study investigated the influence of caffeine ingestion on s-IgA responses to prolonged, intensive exercise. METHODS: In a randomized crossover design, 11 endurance-trained males cycled for 90 min at 70% VO2peak on two occasions, having ingested 6 mg x kg(-1) body mass of caffeine (CAF) or placebo (PLA) 1 h before exercise. Whole, unstimulated saliva samples were collected before treatment (baseline), preexercise, after 45 min of exercise (midexercise), immediately postexercise, and 1 h postexercise. Venous blood samples were collected from a subset of six of these subjects at baseline, preexercise, postexercise, and 1 h postexercise. RESULTS: An initial pilot study found that caffeine ingestion had no effect on s-IgA concentration, secretion rate, or saliva flow rate at rest. Serum caffeine concentration was higher on CAF than PLA at preexercise, postexercise, and 1 h postexercise (P < 0.001). Plasma epinephrine concentration was higher on CAF than PLA at pre- and postexercise (P < 0.05). s-IgA concentration was higher on CAF than PLA at mid- and postexercise (P < 0.01), and s-IgA secretion rate was higher on CAF than PLA at midexercise only (P < 0.02). Caffeine ingestion did not affect saliva flow rate. Saliva alpha-amylase activity and secretion rate were higher on CAF than PLA (main effect for trial, P < 0.05). CONCLUSIONS: These findings suggest that caffeine ingestion before intensive exercise is associated with elevated s-IgA responses during exercise, which may be related to increases in sympathetic activation.
Authors:
Nicolette C Bishop; Gary J Walker; Gabriella A Scanlon; Stephen Richards; Eleanor Rogers
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  38     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-16     Completed Date:  2006-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  513-9     Citation Subset:  IM; S    
Affiliation:
School of Sport and Exercise Sciences, Loughborough University, Loughborough, Leicestershire, United Kingdom. N.C.Bishop@lboro.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Bicycling
Caffeine / administration & dosage*
Cross-Over Studies
Exercise*
Humans
Immunoglobulin A / analysis*
Male
Placebos
Saliva*
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Placebos; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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