| Salivary IgA and periodontal treatment needs in diabetic patients. | |
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MedLine Citation:
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PMID: 22147237 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Salivary IgA can serve as a first line of defense against pathogens that colonize and invade mucosal surfaces and may be protective against periodontal disease. The aim of this study was to assess salivary immunoglobulin A levels in diabetic and non-diabetic patients with different periodontal treatment needs. The Periodontal Screening & Recording (PSR) system was used to evaluate the periodontal treatment needs of 41 diabetic and 42 non-diabetic patients. Unstimulated whole saliva was collected from each patient immediately before clinical examination and stored at -20 °C until analysis. Salivary immunoglobulin A (s-IgA) levels were determined using an enzyme-linked immunosorbent assay, and values were expressed as optical density. Diabetic and non-diabetic patients were compared using clinical and laboratory data. PSR data indicated that periodontal disease was more frequent and more severe in diabetic patients. A higher prevalence of codes 3 and 4 was observed in diabetics as compared with non-diabetics (odds ratio = 2, P < 0.05). Furthermore, non-diabetic patients had more healthy sextants (code 0) than did diabetic patients. Over half of diabetic patients (∼54%) presented with s-IgA levels that were lower than the normal range (optical density from 0.4 nm to 0.6 nm; P < 0.05). In addition, diabetic patients showed a higher variability in s-IgA levels as compared with non-diabetic patients. In conclusion, diabetic individuals had lower s-IgA levels, more-frequent and more-severe periodontal disease, and a greater need for periodontal treatment as compared with non-diabetic patients. |
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Authors:
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Luciana Salles Branco-de-Almeida; Cláudia Maria Coêlho Alves; Fernanda Ferreira Lopes; Adriana de Fátima Vasconcelos Pereira; Rosane Nassar Meireles Guerra; Antônio Luiz Amaral Pereira |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brazilian oral research Volume: 25 ISSN: 1807-3107 ISO Abbreviation: Braz Oral Res Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101307187 Medline TA: Braz Oral Res Country: Brazil |
Other Details:
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Languages: eng Pagination: 550-5 Citation Subset: D; IM |
Affiliation:
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Postgraduate Department, University Center of Maranhão, São Luís, MA, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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