| Saliva transit from the oral cavity to the esophagus in GERD. | |
| | |
MedLine Citation:
|
PMID: 18507067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/AIMS: Normal esophageal acid clearance depends on the neutralization of acid by swallowed saliva, as well as on esophageal peristalsis. This study therefore aimed to investigate the association between saliva production and transport from the oral cavity to the esophagus and developing gastroesophageal reflux disease (GERD) METHODOLOGY: Twenty-eight consecutive patients with GERD symptoms by gastroesophageal reflux self-report questionnaires and 13 healthy volunteers were recruited in the study. After intravenous administration of 99mTc-pertechnetate, anterior sequential imaging was performed every minute for 40 minutes. At 20 minutes after injection of radionuclide, a lemon candy was administered intra-orally to stimulate salivary secretion. Regions of interest (ROI) were selected on the individual oral cavity, the pharynx, and the upper esophagus and time activity curves were drawn for each of these. A time-activity curve in each ROI was subjectively graded, as zero to two-point. The sum of scores in 3 ROIs was considered as a saliva transit total score. RESULTS: The mean transit score of the oral cavity did not differ significantly between GERD patients and healthy volunteers (1.38 vs. 1.61), whereas significantly lower transit scores of pharynx and upper esophagus were found in GERD patients. A 0-point saliva transit score of pharynx and upper esophagus was significantly more frequently detected in GERD patients than in healthy volunteers. CONCLUSIONS: This new modification of saliva scintigraphy is able to evaluate the esophageal motility simply, without a test meal, and to detect impaired saliva transit between pharynx and upper esophagus in GERD patients non-invasively. |
| | |
Authors:
|
Kazuo Hike; Yoshihisa Urita; Toshiyasu Watanabe; Motonobu Sugimoto; Kazumasa Miki |
Related Documents
:
|
21659727 - Iron chelation with deferasirox in two patients with hfe hemochromatosis and chronic an... 7674647 - Effects of a sour bolus on oropharyngeal swallowing measures in patients with neurogeni... 6690877 - Artificial larynx prosthesis: comparative clinical evaluation. 20722047 - Intravenous immunoglobulins for steroid-refractory esophageal involvement related to po... 22354077 - Alzheimer's disease is associated with a low prevalence of hypertension. 23485537 - Prevalence and risk factors of valvular calcification in hemodialysis patients. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hepato-gastroenterology Volume: 55 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2008 Jan-Feb |
Date Detail:
|
Created Date: 2008-05-29 Completed Date: 2008-09-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
|
Languages: eng Pagination: 4-7 Citation Subset: IM |
Affiliation:
|
Department of General Medicine and Emergency Care, Toho University School of Medicine, Omori Hospital, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Esophagus
/
physiopathology*,
radionuclide imaging Female Gastroesophageal Reflux / metabolism* Humans Male Middle Aged Pharynx / metabolism Saliva / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum lipids in parents and siblings of children with Alagille syndrome: a pilot study.
Next Document: NOTES--A new era?