| Saliva substitutes for the treatment of radiation-induced xerostomia--a review. | |
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MedLine Citation:
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PMID: 19495809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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GOAL: The aim of this review is to summarize the in vitro and in vivo evidence on the performance of contemporary saliva substitutes in the treatment of xerostomia and hyposalivation caused by radiation therapy for head and neck malignancies. METHODS: A literature search was conducted during July to September 2008 in PubMed, using the query terms "saliva substitute", "saliva substitute and xerostomia", "artificial saliva", and "artificial saliva and xerostomia"; for clinical studies, only studies in patients suffering from radiation-induced xerostomia have been included in the review. RESULTS AND CONCLUSION: Fifty-two studies met the inclusion criteria and were allotted either to the in vitro topics "viscosity", "lubrication", "wetting properties", "antimicrobial effects", and "enamel and dentin de- and remineralization", or to the in vivo topics "clinical acceptance" or "influence on plaque formation and oral mucosa and microflora". The findings suggest that there are significant differences in the performance of various saliva substitutes concerning the review parameters, yet indicate that further in vitro and in vivo studies on the properties of saliva substitutes are necessary. |
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Authors:
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Sebastian Hahnel; Michael Behr; Gerhard Handel; Ralf B??rgers |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-06-04 |
Journal Detail:
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Title: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Volume: 17 ISSN: 1433-7339 ISO Abbreviation: Support Care Cancer Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-15 Completed Date: 2010-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9302957 Medline TA: Support Care Cancer Country: Germany |
Other Details:
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Languages: eng Pagination: 1331-43 Citation Subset: IM |
Affiliation:
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Department of Prosthetic Dentistry, Regensburg University Medical Center, 93042 Regensburg, Germany. Sebastian.Hahnel@klinik.uni-regensburg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Head and Neck Neoplasms
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complications,
radiotherapy Humans Radiation Injuries / complications, drug therapy Saliva, Artificial / therapeutic use* Salivation / radiation effects Tooth Remineralization Treatment Outcome Xerostomia / drug therapy*, etiology |
| Chemical | |
Reg. No./Substance:
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0/Saliva, Artificial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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