Document Detail


Saliva secretion and oral flora in prolonged nasogastric tube-fed elderly patients.
MedLine Citation:
PMID:  12811948     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In a previous study we showed that prolonged nasogastric tube feeding is associated with pathogenic oral flora. OBJECTIVE: To reexamine the impact of prolonged nasogastric tube feeding on the oral microbiota and to explore the salivary flow and composition in elderly patients in long-term care. METHODS: We compared a group of elderly patients fed by nasogastric tube with a control group of elderly patients in long-term care who are fed orally. Bacteriologic studies were performed by culturing samples from the oropharynx. Saliva studies included quantitative and biochemical analysis of basal and stimulated salivary flow. RESULTS: Bacteriologic studies performed in 90 patients revealed a significantly higher prevalence of gram-negative bacteria in nasogastric tube-fed patients (73% vs. 13%, P < 0.001). It is emphasized that Pseudomonas aeruginosa and Klebsiella pneumoniae were commonly and exclusively isolated from the oral flora of the nasogastric tube-fed patients (P < 0.001, P < 0.05). In the saliva studies performed on 23 nasogastric tube-fed and 21 control patients, basal and stimulated salivary flow was not significantly different in the two groups, however the ratio of stimulated to basal flow was reduced in the nasogastric tube-fed group (P < 0.05). Significant differences were also found in the concentrations of sodium, amylase, phosphor and magnesium. Noteworthy was the concentration of uric acid, the main non-enzymatic antioxidant of saliva, which was significantly lower in nasogastric-tube fed patients (P < 0.002). CONCLUSIONS: These findings suggest that prolonged nasogastric tube feeding is associated with pathologic colonization of the oroparynx and with alterations in the saliva that are related to the risk of aspiration pneumonia. Further research is called for, as well as a thorough revision of the existing oral cleansing procedures in these patients.
Authors:
Arthur Leibovitz; Galina Plotnikov; Beni Habot; Mel Rosenberg; Andi Wolf; Refael Nagler; Eran Graf; Refael Segal
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The Israel Medical Association journal : IMAJ     Volume:  5     ISSN:  1565-1088     ISO Abbreviation:  Isr. Med. Assoc. J.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-06-18     Completed Date:  2003-07-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100930740     Medline TA:  Isr Med Assoc J     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  329-32     Citation Subset:  IM    
Affiliation:
Geriatric Medical Center, Shmuel Harofe Hospital, Beer Yaakov, Israel.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Aged, 80 and over
Colony Count, Microbial
Escherichia coli / isolation & purification*
Female
Humans
Intubation, Gastrointestinal / adverse effects*
Klebsiella / isolation & purification*
Male
Mouth / chemistry,  microbiology*,  secretion*
Oropharynx / chemistry,  microbiology*,  secretion*
Pneumonia, Aspiration / etiology,  microbiology*,  physiopathology*
Pseudomonas aeruginosa / isolation & purification*
Risk Factors
Saliva / chemistry,  microbiology*,  secretion
Salivation / physiology*
Staphylococcus aureus / isolation & purification*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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