Document Detail


Saliva from subjects harboring Actinobacillus actinomycetemcomitans kills Streptococcus mutans in vitro.
MedLine Citation:
PMID:  17335376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous research indicated that patients with localized aggressive periodontitis (LAgP) had minimal proximal decay. We speculated that differences in these two proximal dental diseases (LAgP and proximal decay) in LAgP could be due to the effect of saliva on the growth of key microorganisms related to these two infections. Carbon dioxide (CO(2)) is required for growth of Actinobacillus actinomycetemcomitans (Aa), the reputed cause of LAgP. Bicarbonate, a source of CO(2), buffers acid production by Streptococcus mutans (Sm), a key organism associated with caries. The purpose of this study was to determine whether the saliva of LAgP patients and subjects with Aa had higher levels of bicarbonate, or an elevated pH, and/or reduced survival of Sm. METHODS: Eleven Aa-positive subjects (seven with LAgP) were matched with 11 Aa-negative controls. A total of 5 ml saliva obtained from each subject was tested for CO(2) levels, pH, and effects on survival of Aa and Sm. Saliva from 22 additional subjects was used for confirmatory data. RESULTS: CO(2) levels in the test group (Aa-positive subjects) and controls (Aa-negatives) were similar. No clinically relevant differences were found in salivary pH. However, saliva from the test group killed Sm by more than two logs (P <0.05). No effect was seen on Aa. The saliva from the Aa-negative group killed Aa by two logs (P <0.05). No effect was seen on Sm. CONCLUSION: Aa-positive subjects had a salivary factor that significantly reduced survival of Sm, which may help to explain the fact that this group typically has minimal proximal decay.
Authors:
Daniel H Fine; David Furgang; Daniel Goldman
Related Documents :
21816176 - One-step rt-qpcr with an internal control system for the detection of turkey rotaviruse...
7328466 - Immediate and latent effects induced by the antiallatotropin precocene 2(p2) on embryon...
15334516 - Recurrent respiratory papillomatosis in a survivor of extreme prematurity.
20140376 - Dispersal and survival of nyssomyia intermedia and nyssomyia neivai (diptera: psychodid...
7714506 - Future time perspective and life events across adulthood.
15240636 - Hormonal and body composition predictors of soluble leptin receptor, leptin, and free l...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of periodontology     Volume:  78     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-04-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  518-26     Citation Subset:  D; IM    
Affiliation:
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Newark, NJ 07101, USA. finedh@umdnj.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Actinobacillus actinomycetemcomitans / metabolism*
Adolescent
Adult
Aggressive Periodontitis / complications,  microbiology*
Antibiosis*
Bicarbonates / analysis
Carbon Dioxide / metabolism
Case-Control Studies
Child
Colony Count, Microbial
Dental Caries / complications,  microbiology*
Female
Humans
Hydrogen-Ion Concentration
Male
Microbial Viability
Saliva / chemistry*,  microbiology,  physiology
Streptococcus mutans / metabolism*
Grant Support
ID/Acronym/Agency:
DE-016474/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Bicarbonates; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Early trabecular bone healing around titanium implants: a histologic study in rabbits.
Next Document:  A histologic and histometric assessment of the influence of nicotine on alveolar bone loss in rats.