| Saliva cotinine and thiocyanate: chemical indicators of smokeless tobacco and cigarette use in adolescents. | |
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MedLine Citation:
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PMID: 3236378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent attempts to measure smoking behavior using chemical tests may have been confounded by the use of smokeless tobacco. An objective measure of smokeless tobacco use is needed, particularly among adolescents who may not provide accurate self-reports of tobacco usage. Saliva cotinine was used to distinguish self-reported tobacco users from nonusers and a combination of saliva cotinine and thiocyanate (SCN) tests was used to distinguish smokers from smokeless tobacco users. The subjects were 471 students in grades 7 through 11 who lived in a high-tobacco production area. Approximately 89% of reported nonusers had no detectable cotinine and 99% of nonusers had levels less than 25 ng/ml. Of those who had used tobacco within the last 12 hr, 95% had detectable levels of cotinine. Samples that tested positive for cotinine were also tested for SCN. Eighty-six percent of smokers and 74% of mixed users had SCN values of greater than 1000 mumol/liter, while only 14% of smokeless users had SCN values at that level. The combination of cotinine and SCN was effective in distinguishing smokers from smokeless users but was not effective in distinguishing mixed use from the other two types of use. |
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Authors:
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M P Noland; R J Kryscio; R S Riggs; L H Linville; L J Perritt; T C Tucker |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of behavioral medicine Volume: 11 ISSN: 0160-7715 ISO Abbreviation: J Behav Med Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1989-04-28 Completed Date: 1989-04-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7807105 Medline TA: J Behav Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 423-33 Citation Subset: IM |
Affiliation:
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Health, Physical Education and Recreation Department, University of Kentucky, Lexington 40506. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Cotinine / pharmacokinetics* Female Humans Male Plants, Toxic* Pyrrolidinones / pharmacokinetics* Saliva / metabolism* Smoking / metabolism*, prevention & control Thiocyanates / pharmacokinetics* Tobacco* Tobacco Use Disorder / metabolism*, prevention & control Tobacco, Smokeless* |
| Grant Support | |
ID/Acronym/Agency:
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CA 44004-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Pyrrolidinones; 0/Thiocyanates; 302-04-5/thiocyanate; 486-56-6/Cotinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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