Document Detail

Saliva concentrations of RANKL and osteoprotegerin in smoker versus non-smoker chronic periodontitis patients.
MedLine Citation:
PMID:  18727653     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare the salivary receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin (OPG) concentrations in smokers versus non-smokers with chronic periodontitis. MATERIAL AND METHODS: Whole saliva samples were obtained from 67 untreated chronic periodontitis patients, of whom 34 were smokers, and from 44 maintenance patients, of whom 22 were smokers. Full-mouth clinical periodontal measurements were recorded. Saliva cotinine, sRANKL and OPG concentrations were determined by ELISA. Statistical analysis was performed using the Mann-Whitney U test, Bonferroni's correction for multiple comparisons and Spearman's correlations. RESULTS: Untreated smokers exhibited significantly higher values of clinical periodontal recordings than untreated non-smokers (all p<0.05). Salivary cotinine level correlated with clinical attachment level (p=0.023). Smoker versus non-smoker maintenance groups showed no significant differences in clinical parameters. There were significant differences in sRANKL and OPG concentrations between untreated and maintenance groups (all p<0.01). Salivary OPG concentration was significantly lower (all p<0.01) and the sRANKL/OPG ratio was higher (all p<0.01) in smokers than in non-smokers. OPG concentration correlated positively with probing depth, clinical attachment level and bleeding on probing (all p<0.005) and negatively with pack-year, and cotinine level (p<0.05). CONCLUSION: Salivary RANKL and OPG concentrations are suggested to be affected by smoking as not only the untreated but also the treated smokers exhibited higher RANKL and lower OPG concentrations than non-smokers.
Nurcan Buduneli; Başak Biyikoğlu; Sakhr Sherrabeh; David F Lappin
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Publication Detail:
Type:  Journal Article     Date:  2008-08-24
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  35     ISSN:  1600-051X     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-30     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  846-52     Citation Subset:  D; IM    
Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey.
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MeSH Terms
Case-Control Studies
Chronic Periodontitis / metabolism*
Middle Aged
Osteoprotegerin / metabolism*
RANK Ligand / metabolism*
Saliva / metabolism*
Smoking / metabolism*
Statistics, Nonparametric
Reg. No./Substance:
0/Osteoprotegerin; 0/RANK Ligand

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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