Document Detail

Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data.
MedLine Citation:
PMID:  10098644     Owner:  NLM     Status:  MEDLINE    
In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory and motor nerves.
J S van der Linde-Sipman; T S van den Ingh; J J van nes; H Verhagen; J G Kersten; A C Beynen; R Plekkringa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  36     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-03     Completed Date:  1999-06-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  152-6     Citation Subset:  IM    
Department of Pathology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
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MeSH Terms
Animal Feed / toxicity*
Cat Diseases / chemically induced*,  epidemiology,  pathology
Coccidiostats / poisoning*
Disease Outbreaks / veterinary*
Food Contamination
Ionophores / poisoning
Lameness, Animal / etiology
Netherlands / epidemiology
Peripheral Nerves / pathology
Peripheral Nervous System Diseases / chemically induced,  epidemiology,  pathology,  veterinary*
Pyrans / poisoning*
Reg. No./Substance:
0/Coccidiostats; 0/Ionophores; 0/Pyrans; 53003-10-4/salinomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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