| Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis. | |
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MedLine Citation:
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PMID: 23123626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The polyether ionophoric antibiotics including monensin, salinomycin, and narasin, are widely used in veterinary medicine and as food additives and growth promoters in animal husbandry including poultry farming. Their effects on human health, however, are not fully understood. Recent studies showed that salinomycin is a cancer stem cell inhibitor. Since poultry consumption has risen sharply in the last three decades, we asked whether the consumption of meat tainted with growth promoting antibiotics might have effects on adipose cells. We showed in this report that the ionophoric antibiotics inhibit the differentiation of preadipocytes into adipocytes. The block of differentiation is not due to the induction of apoptosis nor the inhibition of cell proliferation. In addition, salinomycin also suppresses the transcriptional activity of the CCAAT/enhancer binding proteins and the peroxisome proliferator-activated receptor γ. These results suggest that the ionophoric antibiotics can be exploited as novel anti-obesity therapeutics and as pharmacological probes for the study of adipose biology. Further, the pharmacological effects of salinomycin could be a harbinger of its toxicity on the adipose tissue and other susceptible target cells in cancer therapy. |
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Authors:
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Maria Szkudlarek-Mikho; Rudel A Saunders; Sook Fan Yap; Yun Fong Ngeow; Khew-Voon Chin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-10-31 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 428 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-12-03 Completed Date: 2013-03-26 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 487-93 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine, Biochemistry and Cancer Biology, Center for Diabetes and Endocrine Research, College of Medicine, University of Toledo, Toledo, OH 43614, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipogenesis
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drug effects*,
genetics Animals Anti-Bacterial Agents / chemistry, pharmacology* CCAAT-Enhancer-Binding Protein-alpha / metabolism Cell Line Ionophores / chemistry, pharmacology* Microphthalmia-Associated Transcription Factor / metabolism PPAR gamma / metabolism Promoter Regions, Genetic / drug effects Pyrans / chemistry, pharmacology* Transcription, Genetic / drug effects Transcriptional Activation / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA102204/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/CCAAT-Enhancer-Binding Protein-alpha; 0/Ionophores; 0/Microphthalmia-Associated Transcription Factor; 0/PPAR gamma; 0/Pyrans; 62UXS86T64/salinomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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