Document Detail


Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis.
MedLine Citation:
PMID:  23123626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The polyether ionophoric antibiotics including monensin, salinomycin, and narasin, are widely used in veterinary medicine and as food additives and growth promoters in animal husbandry including poultry farming. Their effects on human health, however, are not fully understood. Recent studies showed that salinomycin is a cancer stem cell inhibitor. Since poultry consumption has risen sharply in the last three decades, we asked whether the consumption of meat tainted with growth promoting antibiotics might have effects on adipose cells. We showed in this report that the ionophoric antibiotics inhibit the differentiation of preadipocytes into adipocytes. The block of differentiation is not due to the induction of apoptosis nor the inhibition of cell proliferation. In addition, salinomycin also suppresses the transcriptional activity of the CCAAT/enhancer binding proteins and the peroxisome proliferator-activated receptor γ. These results suggest that the ionophoric antibiotics can be exploited as novel anti-obesity therapeutics and as pharmacological probes for the study of adipose biology. Further, the pharmacological effects of salinomycin could be a harbinger of its toxicity on the adipose tissue and other susceptible target cells in cancer therapy.
Authors:
Maria Szkudlarek-Mikho; Rudel A Saunders; Sook Fan Yap; Yun Fong Ngeow; Khew-Voon Chin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-31
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  428     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-03-26     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  487-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adipogenesis / drug effects*,  genetics
Animals
Anti-Bacterial Agents / chemistry,  pharmacology*
CCAAT-Enhancer-Binding Protein-alpha / metabolism
Cell Line
Ionophores / chemistry,  pharmacology*
Microphthalmia-Associated Transcription Factor / metabolism
PPAR gamma / metabolism
Promoter Regions, Genetic / drug effects
Pyrans / chemistry,  pharmacology*
Transcription, Genetic / drug effects
Transcriptional Activation / drug effects
Grant Support
ID/Acronym/Agency:
R01 CA102204/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/CCAAT-Enhancer-Binding Protein-alpha; 0/Ionophores; 0/Microphthalmia-Associated Transcription Factor; 0/PPAR gamma; 0/Pyrans; 62UXS86T64/salinomycin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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