Document Detail

Saline versus Saline with Blood as a Contrast Agent for Right-to-left Shunt Diagnosis by Transcranial Doppler: Is There a Significant Difference?
MedLine Citation:
PMID:  20977529     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND AND PURPOSE: Agitated saline solution (AS) is the contrast agent (CA) of choice for the diagnosis of right-to-left shunt (RLS). The aim of this study was to compare AS to AS with blood (ASb) in the diagnosis and quantification of RLS by contrast-enhanced transcranial Doppler (cTCD).
METHODS: Forty-two patients were evaluated for RLS in both of the middle cerebral arteries (MCA) by cTCD. Both AS and ASb were used as CAs while the patient breathed spontaneously and during two different moments of a Valsalva maneuver. Embolus track (ET) counts were obtained from each MCA (MCA analysis) and from each patient (patient analysis).
RESULTS: In the MCA analysis, at least one ET was identified in 109 (43.2%) of the AS tests and 136 (54%) of the ASb tests (P= .016). The ET counts were higher with ASb (78.0 ± 117.6) than with AS alone (46.9 ± 66.7; P= .01). In the patient analysis, at least one ET was identified in 62 (49.2%) of the AS tests and 77 (61.1%) of the ASb tests (P= .057). Similar ET counts were generated with both CA solutions.
CONCLUSIONS: These findings support the inclusion of ASb as an option for RLS diagnosis in selected patients.
Marcos Christiano Lange; Viviane Flumignan Zétola; Elcio J Piovesan; Lineu César Werneck
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Publication Detail:
Type:  Journal Article     Date:  2010-10-26
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  22     ISSN:  1552-6569     ISO Abbreviation:  J Neuroimaging     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 by the American Society of Neuroimaging.
From the Neurology Division, Internal Medicine Department, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Brazil.
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